Results 171 to 180 of about 23,920,837 (347)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Renewable Energy: Hydropower [PDF]
This lesson introduces students to the use of flowing or falling water (hydropower) to perform work, particularly electric power generation. Topics include the history of hydropower development, the invention of turbines and electric generators, and the ...
John Pratte
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
How Humans Change the Atmosphere [PDF]
This exercise is designed to introduce students to the idea that human activities can alter the chemistry or gaseous composition of the atmosphere, resulting in a variety of impacts on human health and the environment.
Chris Fox
core
Accrual-Based and Real Earnings Management Activities Around Seasoned Equity Offerings
, 2010 D. Cohen, Paul Zarowin
semanticscholar +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Tectonic Plate Movements and Hotspots [PDF]
This lesson introduces the idea that rates and directions of plate movements can be measured. The discussion centers on the use of mantle 'hotspots' to determine plate motions.
Ken Rhinehart
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Activities and Time Spent on Rehabilitation in Scandinavian ICUs: A Cross-Sectional Survey Among Healthcare Professionals. [PDF]
Acta Anaesthesiol ScandAlfheim HB +7 more
europepmc +1 more source