Results 261 to 270 of about 14,136,893 (299)

Physical activities, longevity gene, and all-cause mortality among older adults: a prospective community-based cohort study. [PDF]

BMC Med
Xu L, Wang J, Li X, Li Y, Chen C, Xu Z, Xia Y, Lu Z, Zhou J, Zhang M, Wei Y, Wu B, Zhang Z, Li F, Luo Y, Chen G, Lv Y, Shi X.   +17 more
europepmc   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Elements of healthcare delivery required to facilitate the clinical governance of hospital pharmacy services: a document review. [PDF]

Health Res Policy Syst
Balikubiri H, Kemp-Casey A, Andrade AQ, Roughead EE.   +3 more
europepmc   +1 more source

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

Molecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan, Moshe Leitner, Amos Toren, Shoshana Paglin, Michal Yalon   +4 more
wiley   +1 more source

How Art Museums Can Foster the Flourishing of Future Physicians. [PDF]

Perspect Med Educ
Liu WL, Chisolm MS.
europepmc   +1 more source

THE ACTIVITY OF DIFFERENT STEROIDS IN PRODUCING THYMIC INVOLUTION

, 1957
Jennifer Shewell
openalex   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Stress Response of <i>Siniperca chuatsi</i> to Transport Stimuli Using Compound Feed and Live Bait. [PDF]

Animals (Basel)
Duan Y, Li Q, Huang Z, Zhao Z, Zhao H, Feng Y, Liu S, Mou C, Zhou J, Zhang L.   +9 more
europepmc   +1 more source

The Biochemical Activity of 6-Azauridine: Interference with Pyrimidine Metabolism in Transplantable Mouse Tumors

, 1959
C. A. Pasternak, Robert E. Handschumacher   +1 more
openalex   +1 more source