Results 171 to 180 of about 2,034,059 (380)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

The impact of a residential fire on occupational engagement and performance: A reflexive narrative approach

Burns Open
Residential fires are a devastating and stressful life event. The high number of residential fires per year and significant associated stressors impacts all aspects of daily life.
Gregory Chown
doaj   +1 more source

An introductory study of common grasps used by adults during performance of activities of daily living [PDF]

, 2014
Margarita Vergara, Joaquín L. Sancho-Bru, Verónica Gracia-Ibáñez, Antonio Pérez-González   +3 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Activities of Daily Living of Patients with Malignant Brain Tumors Assessed By Using Functional Independence Measurement Scoring System

, 2015
Hiroshi Kanno Jo Sasame
openalex   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Cognitive dysfunction, social participation, and performance of activities of daily living among a sub-urban community-dwelling older adults in Nigeria

Cogent Gerontology
Cognitive dysfunction (CF) in older adults significantly impacts activities of daily living (ADLs), social participation (SP), instrumental activities of daily living (IADLs), and overall quality of life. This cross-sectional study assessed CF, SP, ADLs,
Obiekwe Sochima Johnmark, Uzoamaka Nwakego Akobundu, Okwudili Precious Emuka, Akosile Christopher Olusanjo, Uchechukwu Martha Chukwuemeka, Ukamaka Gloria Mgbeojedo, Uchenna Prosper Okonkwo   +6 more
doaj   +1 more source

Does Working Longer Make People Healthier and Happier? [PDF]

PURPOSE: This study addresses the impact of late-life paid work on physical and psychological well-being. METHODS: Longitudinal data was drawn from the Health and Retirement Survey and the RAND-HRS data base for more than 6,000 individuals aged 59 to 69 ...
Calvo, Esteban
core   +1 more source

Nutritional status and independence in instrumental activities of daily life in the elderly living in nursing homes and community dwellings: A comparative study

, 2018
Samia Farouk Mahmoud, Hanady Gaber Sheha
openalex   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source