Results 81 to 90 of about 191,503 (337)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

open access: yesFEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand   +2 more
wiley   +1 more source

Evaluation of the cost price of conventional laboratory services in the selected hospital of Tehran University of Medical Sciences and its comparison with the tariffs approved by the Ministry of Health and Medical Education in 2019

open access: yesبیمارستان, 2020
Background: Considering the importance and position of the health sector in socio-economic development programs, it is necessary to be aware of the current situation and to recognize its issues and problems.
Hojjat Rahmani   +4 more
doaj  

Deagnostic market feedback attenuates the benefits of ABC for competitive price setting in a heterogeneous market. [PDF]

open access: yes
Activity-Based Costing (ABC) is intended to assist managers to make better pricing decisions than those taken using traditional volume-based cost methods.
Cardinaels, Eddy   +2 more
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

PENGARUH ACTIVITY BASED COSTING SYSTEM (ABC SYSTEM) TERHADAP KINERJA PERUSAHAAN DAN DAMPAKNYA PADA KEUNGGULAN BERSAING (Studi Pada PT Bio Farma) [PDF]

open access: yes, 2017
ABSTRAK Penelitian ini bertujuan untuk meneliti secara empiris mengenai pengaruh activity based costing system terhadap kinerja perusahaan dan dampaknya pada keunggulan bersaing pada perusahaan Bio Farma (Persero).
WIWIN CAHYANI, 134020256
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

PENERAPAN METODE ACTIVITY-BASED COSTING SYSTEM DALAM MENENTUKAN BESARNYA TARIF JASA RAWAT INAP (Study Kasus pada Rumah Sakit Islam Klaten) [PDF]

open access: yes, 2010
Tujuan penelitian ini adalah mengetahui perhitungan biaya rawat inap dengan Activity Based Costing System. Selain itu juga membandingkan penghitungan biaya rawat inap dengan metode yang digunakan rumah sakit dan Activity Based Costing System ...
NUGROHO , WAHYU
core  

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

open access: yesFEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Home - About - Disclaimer - Privacy