Results 211 to 220 of about 18,252,443 (306)

Research activity survey 2003 [PDF]

, 2003

core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Human Cerebral Blood Flow Activity with Diurnal Variation Differentially Correlated with the Suprachiasmatic Nucleus. [PDF]

J Neurosci
Ogawa A, Oka S, Osada T, Tanaka M, Chen W, Kamagata K, Aoki S, Nakamura TJ, Konishi S.   +8 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Preclinical characterization of AZD1163, a first-in-class anti-PAD2/4 bispecific antibody for the treatment of rheumatoid arthritis. [PDF]

MAbs
Sims GP, Scaletta L, Andrews J, Sims DA, Strain M, Sigurdardottir A, Kuriakose T, England E, Rajasinghe L, Jiang F, Xiong X, Neal F, Vinall L, Newton P, Boger E, Kim C, Dahlbäck H, Prothon S, Leander J, Darrah E, Collins M, Douglas G, White N, Day K, Vousden KA, Huntington CE, Close D.   +26 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Activity of ice-binding proteins can be markedly enhanced by protein tags.

Nanoscale
van den Broek D, Giezen SN, Hogervorst TP, de Vries R, Voets IK.   +4 more
europepmc   +1 more source

A latent profile analysis of physical activity participation patterns and mental health among university students: the mediating role of emotion regulation. [PDF]

Sci Rep
Chen L, Ke W, Li G, Chen J.
europepmc   +1 more source