Evaluation of two intraoperative gamma detectors for assessment of 177Lu activity concentration in vivo. [PDF]
EJNMMI Phys, 2017 Sandblom V +3 more
europepmc +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Regional specialisation and location of industrial activity in accession countries [PDF]
Central and East European economies have experienced since 1990 increasing integration with the European Union via trade and foreign direct investments. The spatial implications of this process have been, so far, little investigated.
Traistaru, Iulia +2 more
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
European Integration and Regional Specialization Patterns in Turkey's Manufacturing Industry [PDF]
The dynamics of industrial agglomeration across the regions and the reasons for such agglomeration have been the focus of interest particularly in exploring the effects of economic integration of regions on the spatial distribution of economic activity ...
Pinar Falcioglu, Sedef Akgüngör
core
SPECT image segmentation for estimation of tumour volume and activity concentration in 177Lu-DOTATATE radionuclide therapy. [PDF]
EJNMMI Res, 2017 Gustafsson J +2 more
europepmc +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Using Spectrophotometry to Determine Concentration
, 2012 This lab activity from the Biotechnology Alliance for Suncoast Biology Educators (BASBE) demonstrates the principles of spectrophotometry. It also allows students to develop a testable hypothesis about the chlorophyll concentration in different olive oil
Keirle, Matt
core
Longitudinal monitoring of reconstructed activity concentration on a clinical time-of-flight PET/CT scanner. [PDF]
J Med Imaging (Bellingham), 2017 MacDonald LR, Perkins AE, Tung CH.
europepmc +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source