Results 111 to 120 of about 659,826 (317)
, 2012 The 2012 activity diagram comprises three main axes from which different actions emerge. The three axes are: presentation of the program methodology, teamwork with other institutions and conducting educational events.
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Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Model Transformations between Sequence Diagram and Activity Diagram with QVTo
, 2022 Complex software systems are specified by various models denoting the behavior of the system components, the exchanges of messages and data among components, the intents of the system stakeholders, the flow of system processes, and the structure of the system as a collection of modules. When such systems are maintained and evolved (e.g.
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Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
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Towards Extending UML's Activity Diagram for the Architectural Modeling, Analysis, and Implementation [PDF]
Annals of computer science and information systems, 2020 Mehmet Alp Kose, Mert Ozkaya
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Pengembangan Sistem Informasi Dengan Metode Waterfall Untuk Pengarsipan Data Wajib Pajak
Techno.Com, 2017 Kantor pelayanan pajak (KPP) merupakan Kantor yang berfungsi melayani wajib pajak dalam aktivitas pembayaran pajak. Kantor Pelayanan Pajak sejatinya mempunyai data-data yang terkait dengan wajib pajak.
Yani Parti Astuti, Egia Rosi Subhiyakto
doaj
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source