Results 121 to 130 of about 1,625,987 (302)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Lunar Surface Gravimeter Experiment [PDF]

The lunar surface gravimeter which was emplaced on the moon by the Apollo 17 flight is described and a schematic diagram of the sensor is provided. The objective of the lunar surface gravimeter is to use the moon as an instrumented antenna to detect ...
Giganti, J. J., Larson, J. V., Richard, J. P., Weber, J.   +3 more
core   +1 more source

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Metamodel-Based Compaction of Spacecraft Operational Scenario Models for Efficient Review

IEEE Access
Owing to the difficulty in performing repairs during flight, spacecraft are operated according to the operational scenarios tested before launch. Operational models, which are a type of SysML activity diagram, can be used to depict these scenarios using ...
Kazunori Someya, Toshiaki Aoki, Naoki Ishihama   +2 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

LMS Implementation in High Schools in Eastern Indonesia After the Covid-19 Pandemic

Journal of Education Technology
The Covid-19 pandemic had prevented students and teachers from carrying out teaching and learning activities in physical classroom due to activity restrictions, social distancing, or lockdown. The problem that occurs is the unavailability of an IT-based
Budi Yulianto, Rita Layona
doaj   +1 more source

Dynamics of new strain emergence on a temporal network

, 2018
Multi-strain competition on networks is observed in many contexts, including infectious disease ecology, information dissemination or behavioral adaptation to epidemics.
Chakraborty, Sukankana, Hoffmann, Xavier R., Leguia, Marc G., Nolet, Felix, Ortiz, Elisenda, Poletto, Chiara, Prunas, Ottavia, Valdano, Eugenio, Zavojanni, Leonardo   +8 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Application of Vee Diagram in Reconstructing Laboratory Activity Design on Diffusion-Osmosis Concept

Quagga
Implementing the Merdeka curriculum is a record of Indonesia's long journey of education dynamics. One of the reforms visible from implementing the Merdeka curriculum is the existence of science process skills (KPS), as stated in the learning outcomes ...
Ahmad Soleh, Widi Purwianingsih, Kusnadi, Bambang Supriatno, Amprasto   +4 more
doaj   +1 more source