Results 151 to 160 of about 659,826 (317)

Mapping SPEM Process Specifications to Activity Cycle Diagrams

, 2018
Rodrigo Martins Pagliares, Celso Massaki Hirata   +1 more
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Regioselective synthesis of novel spiro-isoxazolines congeners as antimicrobial agents: <i>in vitro</i> and <i>in-silico</i> assessments. [PDF]

Front Chem
Bouzammit R, Ait Assou S, Er-Rajy M, Aflak N, Bahsis L, Chalkha M, El Hassouni M, Lachkar M, Ben Hadda T, Benson D, Alyousef AA, Aboul-Soud MAM, Giesy JP, Al Houari G.   +13 more
europepmc   +1 more source

Semantic foundation and tool support for model-driven development with UML 2 activity diagrams

, 2006
Stefan Sarstedt
openalex   +2 more sources

Physiologically motivated multiplex Kuramoto model describes phase diagram of cortical activity [PDF]

, 2015
Maximilian Sadilek, Stefan Thurner
openalex   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Lower Critical Solution Temperature Phase Behavior and Water Activity of a Ternary Mixture of Oleic Acid, Lidocaine, and Water. [PDF]

J Chem Eng Data
Kocher JD, Mahfouz A, Bell HT, Rinehart JM, Menon AK.   +4 more
europepmc   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Modelling dysfunction-specific interventions for seizure termination in epilepsy. [PDF]

NPJ Syst Biol Appl
Kamaraj AK, Szuromi MP.
europepmc   +1 more source

Activity-based user equilibrium considering aggregated traffic dynamics emulated using the Macroscopic Fundamental Diagram

Sérgio Batista, Guido Cantelmo, Mónica Menéndez, Constantinos Antoniou, Ludovic Leclercq   +4 more
openalex   +1 more source