FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source
Phototropin monitors actual temperature, not temperature difference, to regulate temperature-dependent chloroplast movement via cis-trans autophosphorylation mode switching in Marchantia polymorpha. [PDF]
PlantaNoguchi M +3 more
europepmc +1 more source
Physiologically motivated multiplex Kuramoto model describes phase\n diagram of cortical activity [PDF]
, 2014 Maximilian Sadilek, Stefan Thurner
openalex +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Paraventricular nucleus-locus coeruleus VGlut2 neural circuit regulates energy metabolism in mice. [PDF]
Cell Death DisLiu H +19 more
europepmc +1 more source
HSP70 governs permeability and mechanotransduction in primary human endothelial cells
FEBS Open Bio, EarlyView.HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez +5 more
wiley +1 more source
Global research hotspots and emerging trends in orthopedic robotic surgery: a comprehensive bibliometric analysis. [PDF]
J Robot SurgYang Z +5 more
europepmc +1 more source
The method of structured transformation of a business process activity diagram into a context map of domain-driven design [PDF]
Serhii Moskovko, Roman Kvyetnyy
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Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source