The method of structured transformation of a business process activity diagram into a context map of domain-driven design [PDF]
Serhii Moskovko, Roman Kvyetnyy
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Production of antibacterial compounds by a Steely hybrid polyketide synthase in Dictyostelium
FEBS Open Bio, EarlyView.By selecting appropriate production species under optimised culture conditions, new chlorinated dibenzofuran compounds, which previously could not be analysed in sufficient quantities, were identified from cellular slime mould fruiting bodies. The strong antibacterial activity exhibited by these compounds suggests a link to the ecological function of ...
Tomoaki R. Yamashita +3 more
wiley +1 more source
Anti-diabetic effects of Dachaihu decoction combined with <i>Sanghuangporus vaninii</i>: insights from network pharmacology, intestinal flora, and liver metabolomics. [PDF]
Front Cell Dev BiolHuang J +6 more
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FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
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Coptisine regulates PI3K/AKT pathway to block bladder cancer progression: a study based on network pharmacology, in vitro and in vivo assays. [PDF]
HereditasXiaohui Y, Jie L, Jiangqiao Z.
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FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
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Case Report: Identification of a novel pathogenic <i>UGT1A1</i> mutation in a Chinese patient with Gilbert syndrome. [PDF]
Front Med (Lausanne)Zhao C, Huang H.
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A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
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Flavonoids as Immunoregulators: Molecular Mechanisms in Regulating Immune Cells and Their Therapeutic Applications in Inflammatory Diseases. [PDF]
Front ImmunolLiu Y, Jiao A.
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Syntactic and Semantic Extensions of Malicious Activity Diagrams to Support ISSRM
, 2013 Othmar OthmarMwambe
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