Results 91 to 100 of about 377,299 (238)
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Association of daily health behavior and activity of daily living in older adults in China. [PDF]
Sci Rep, 2023 Wang LY, Feng M, Hu XY, Tang ML.
europepmc +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
National Journal of Community MedicineBackground: Improving the quality of life for India's increasing senior population is a pressing public health issue. The proportion of seniors has risen from 5.6% in 1961 to 8.6% in 2011 and is projected to reach 12.5% by 2030, escalating further to 20%
Ashmitha Rajan +4 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Effects of Dietary Pattern on Day to Day Activities in Multiple Sclerosis Patients
Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2011 Introduction: Multiple Sclerosis Disease is the most common neurological demyelinization disorder in young adults that leads to their disability. Because of the side effects of treatment drugs, it seems that another method should be used.
F Rashvand +5 more
doaj
The relationship between intrinsic capacity and functional ability in older adults
BMC GeriatricsIntroduction Intrinsic Capacity in integrated geriatric care emphasizes the importance of a thorough functional assessment. Monitoring the intrinsic capacity of older individuals provides standardized and reliable information to prevent early disability.
Somayeh Ahmadi +3 more
doaj +1 more source
Association Between Mobilization Level And Activity of Daily Living Independence in Critically Ill Patients. [PDF]
Ann Rehabil Med, 2023 Watanabe S +8 more
europepmc +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Publisher Correction: Association of daily health behavior and activity of daily living in older adults in China. [PDF]
Sci Rep, 2023 Wang LY, Feng M, Hu XY, Tang ML.
europepmc +1 more source