Results 131 to 140 of about 377,299 (238)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Activities of Daily Living

, 2016
Measurement of ability or inability to perform activities of daily living (ADLs) is important to in describing the functional status of a person and then implementing an intervention. Evaluations of ADLs are mainly used in nursing and in rehabilitation of people with disabilities and the elderly.
openaire   +4 more sources

Comparison of the Quantitative Myasthenia Gravis and Myasthenia Gravis Activity of Daily Living Scores From a Clinical Practice Perspective. [PDF]

Muscle Nerve
Wu W, Petersson M, Piehl F, Brauner S.
europepmc   +1 more source

Living with heart failure: patient experiences and implications for physical activity and daily living. [PDF]

ESC Heart Fail, 2022
Niklasson A, Maher J, Patil R, Sillén H, Chen J, Gwaltney C, Rydén A.   +6 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Dependência funcional de idosos e a sobrecarga do cuidador

Revista da Escola de Enfermagem da USP
A finalidade deste estudo foi identificar a dependência funcional de idosos e a sobrecarga do cuidador. Trata-se de estudo epidemiológico e transversal realizado em 2009 com 574 idosos e 124 cuidadores em Ribeirão Preto-SP, por meio dos instrumentos MIF ...
Aline Cristina Martins Gratão, Luana Flávia da Silva Talmelli, Leandro Corrêa Figueiredo, Idiane Rosset, Cibele Peroni Freitas, Rosalina Aparecida Partezani Rodrigues   +5 more
doaj  

The role of instrumental activity of daily living disability in the association between circadian syndrome and cardiometabolic multimorbidity in Chinese middle-aged and older adults. [PDF]

J Health Popul Nutr
Fang Y, Wu D, Shi Z, Shen J, Liu E, Wu X, Hu W, Lv L.   +7 more
europepmc   +1 more source

Impact of COVID-19 Pandemic on Rate of Cognitive Impairment Screening Among the Elderly by Activity of Daily Living in Indochina: A Preliminary Report. [PDF]

Dement Neurocogn Disord, 2023
Mungmunpuntipantip R, Wiwanitkit V.
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Nursing Program Promoting the Activity of Daily Living Among Older Adults Admitted to Semimedical Intensive Care Units: A Quasi-Experimental Study. [PDF]

Nurs Res Pract
Sommana C, Banharak S, Limpawattana P, Sim-Im S, Pimpun P, Somkamsri T, Seeharach O, Chaisomsee S, Donsrichan W, Luejunda B, Navanukul S.   +10 more
europepmc   +1 more source