Results 241 to 250 of about 8,106,141 (300)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

An IoT-enabled CRNN framework for secure wearable sensor-based activity recognition in physical education. [PDF]

Sci Rep
Yuan J, Zhang Y, Chen B.
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Dynamic-Attentive Selective Mamba with Group-Aware Convolution for Wearable Sensor-Based Sports and Daily Activity Recognition. [PDF]

Sensors (Basel)
Li Z, Kang W.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Agile human activity recognition for wearable devices based on online incremental learning. [PDF]

Front Public Health
Fan L, Peng H, Xiao L, Shi L, Zhou S, Song Y, Fan H.   +6 more
europepmc   +1 more source

Efficient Thermal Pose Estimation: Balancing Accuracy and Edge Deployment for Smart Home Activity Recognition. [PDF]

Sensors (Basel)
Vdoviak G, Sledevič T, Abromavičius V, Navakauskas D, Kaklauskas A.   +4 more
europepmc   +1 more source

Subject-independent gait activity recognition using DSAF: dual-stream IMU-EMG attention fusion with asymmetric temporal encoding and physiological complementarity weighting. [PDF]

Front Neurorobot
Xu Z, Zhu Y, Li S.
europepmc   +1 more source

Integrating multi-scale convolution and attention mechanisms in HybridHAR for high-performance human activity recognition. [PDF]

Sci Rep
Huo Y, Wei C, Xu Z, Liu Z, Jin M, Zhang Z.   +5 more
europepmc   +1 more source

Self-Powered Flexible Triboelectric-Gated Ion-Gel Transistor for Neuromorphic Tactile Sensing and Human Activity Recognition. [PDF]

Adv Mater
Cho H, Park S, Lee Y, Lee S.
europepmc   +1 more source