Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source
Seasonal differences in mobility and activity space in later life: a case study of older adults in the Northern Netherlands. [PDF]
Meijering L +3 more
europepmc +1 more source
An activity space approach to understanding how food access is associated with dietary intake and BMI among urban, low-income African American women. [PDF]
Raskind IG +4 more
europepmc +1 more source
A Study on Improving Campus Spaces for Physical Activity using AI-Based Analysis [PDF]
Myung-Jae Hwang +6 more
openalex +1 more source
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
Activity space during treatment with medication for opioid use disorder: Relationships with personality, mood, and drug use. [PDF]
Panlilio LV +6 more
europepmc +1 more source
Improving Activity Requirements in Open Plan Office Spaces by Using Different Acoustic Design Elements: Engineering Studies and Consultation Center as a Case Study [PDF]
Sanaa Abdelghany Eldyasty Ahmed Eid +2 more
openalex +1 more source

