Results 61 to 70 of about 11,031 (215)

The symmetry principle and the concept of time in actor-network theory [PDF]

Соціологія, 2019
The article addresses some problems of interpreting the symmetry principle and the concept of time in actor-network theory (ANT). The relationships between human and non-human actors constitute the basis for one of the key theses in ANT, which is the ...
Mykhailo Akulov
doaj  

Waste Struggle: Political Ecology Analysis on Urban Waste Conflict in Pekanbaru [PDF]

E3S Web of Conferences
This article analyzes waste management conflict in Pekanbaru through the perspectives of political ecology and Actor-Network Theory (ANT). Based on rapid ethnographic research conducted in West Tangkerang Village, Marpoyan Damai District, the findings ...
El Amady M. Rawa, Yanti Rina Novia
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Aerial Digital Archaeology and Data Ethics through the Lens of Actor-Network Theory

Ethics in Progress
Actor-network theory emphasizes the importance of technology in archaeological research, particularly in aerial digital archaeology. It deconstructs objective narratives by revealing the complexity of knowledge production, including the archaeologist’s ...
Sayumphu Ros
doaj   +1 more source

Actor-Network Theory: Insights into the Study of Social-Ecological Resilience. [PDF]

Int J Environ Res Public Health, 2022
Yao S, Liu K.
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Review essay: Recovering assemblages: Unfolding sociomaterial relations of drug use and recovery by Aysel Sultan

International Journal of Narrative Therapy and Community Work
Tom Strong reviews Aysel Sultan (2022). Recovering assemblages: Unfolding sociomaterial relations of drug use and recovery. Palgrave Macmillan. 290pp. ISBN 978-981-19-1234-4, ISBN 978-981-19-1235-1 (eBook).
Tom Strong
doaj   +1 more source

Intersectoral Collaboration to Promote Child Development: The Contributions of the Actor-Network Theory. [PDF]

Qual Health Res, 2023
Chiari APG, Senna MIB, Gomes VE, Freire MDSM, Soares ARDS, Alves CRL, Cury GC, Ferreira RC.   +7 more
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source