Results 71 to 80 of about 1,332,411 (242)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Potencial de innovación y gestión institucional en la Universidad Nacional de Cañete-Perú

open access: yesSophía: Colección de Filosofía de la Educación, 2020
La presente investigación parte del marco de las múltiples y complejas transformaciones políticas, económicas, sociales y culturales que plantea el sistema universitario actual, surge de la necesidad de desarrollar diagnósticos certeros del potencial ...
Dulio Oseda Gago   +2 more
doaj   +1 more source

Boy meets goal, boy loses goal, boy gets goal : the nature of feedback between goal-based simulation and understanding systems [PDF]

open access: yes, 1981
We are designing a goal-based planning and simulation system called REACTOR for a multiple-actor world in which partially formulated plans are monitored during execution, providing feedback to the planner.
Meehan, James R.
core   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Harvesting living labs outcomes through learning pathways

open access: yesCurrent Research in Environmental Sustainability
Living labs have emerged as a long-term, collaborative approach to addressing complex societal challenges, such as sustainable land and water management and climate change adaption.
Astha Bhatta   +2 more
doaj   +1 more source

An actor-network theory (ANT) approach to Turkish e-government gateway initiative [PDF]

open access: yes, 2009
There are various models proposed in the literature to analyze trajectories of e-Government projects in terms of success and failure. Yet, only the Actor-Network Theory (ANT) perspective (Heeks and Stanforth, 2007) considers the interaction factors among
Aykac, D. Selcen O.   +4 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Artificial Intelligence and Civil Liberties in Nigeria

open access: yesNsukka Journal of Religion and Cultural Studies
Artificial intelligence (AI) offers significant potential for governance, public service delivery, and security in Nigeria. However, its deployment raises serious concerns for civil liberties, especially freedom of expression, non-discrimination ...
Emmanuel Actor Oyewole   +1 more
doaj   +1 more source

The changing nature of urban public places in Dhaka City [PDF]

open access: yesUrbanism. Arhitectura. Constructii, 2014
Throughout the history, public places have been asserted as one of the key components of urban life for their physical, social, political, symbolic and environmental roles.
Mashrur Rahman Mishu   +2 more
doaj  

Ontology-Mediated Historical Data Modeling: Theoretical and Practical Tools for an Integrated Construction of the Past

open access: yesInformation, 2020
Building upon the concepts of constructed past theory, this paper introduces the outcome of ontology-mediated data modeling developed by the authors within the last 15 years.
Esther Travé Allepuz   +2 more
doaj   +1 more source

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