Results 41 to 50 of about 11,180 (240)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Problem of Relevance in Post-Actor-Network Theory
Социология властиThe article is devoted to the problem of relevance in post-actor network theory. In the context of the turn to the material in sociological theory, one of the key tasks is to determine the relevance of non-humans in social interactions or in broader ...
M. D. Malkov
doaj +1 more source
Interfaces Numériques, 2019 This contribution conceives of interactive documentaries as relational configurations – as a nexus of discourses and practices. By building theory from practice (i.e. two case studies of interactive documentaries), the axioms of Actor Network Theory will
Anna Wiehl
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Meeting the Universe Halfway. Feminist debate and Actor-Network Theory
Tecnoscienza, 2010 Starting from Karen Barad’s volume Meeting the Universe Halfway, Quantum Physics and the Entanglement of Matter and Meaning, I intend to focus on some points of convergence and divergence between two different debates on STS: the feminist approach and ...
Restituta Castiello
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Iranian Journal of Information Processing & Management, 2013 Actor network theory as a qualitative approach to study complex social factors and process of socio-technical interaction provides new concepts and ideas to understand socio-technical nature of information systems. From the actor network theory viewpoint,
Maryam Sharifzadeh +4 more
doaj
Entrepreneurship and Sustainability IssuesSmart Specialisation Strategies, their planning and implementation are becoming more important in Europe's transition but also bring up several challenges, especially when it comes to complex innovation processes and requirements arising from the call ...
Christopher Meyer
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source