Results 101 to 110 of about 18,656 (203)

Performance improvement of discrete‐time linear‐quadratic regulators applied to uncertain linear systems using the Tikhonov regularization method

Asian Journal of Control, EarlyView.
Abstract The linear‐quadratic regulator (LQR) problem of optimal control of an uncertain discrete‐time linear system (DTLS) is revisited in this paper from the perspective of Tikhonov regularization. We show that an optimally chosen regularization parameter reduces, compared to the classical LQR, the values of a scalar error function, as well as the ...
Fernando Pazos, Amit Bhaya
wiley   +1 more source

Pharmacokinetic, Safety, and Immunogenicity Similarity of High- and Low-Concentration Formulations of Adalimumab Biosimilar ABP 501, Adalimumab-Atto. [PDF]

Pharmacol Res Perspect
Chow V, Zhou M, Mytych DT, Colbert A, Miller MJ, Wala I, Sabet A, Radziszewski W.   +7 more
europepmc   +1 more source

Simulating competition in the US bioeconomy to produce hard‐to‐electrify transportation fuels using limited biomass resources

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract This study presents a novel bioeconomy optimization framework, BiOpt, designed to address critical questions regarding the strategic use of limited US biomass resources for biofuel production. By integrating detailed techno‐economic analyses, life cycle assessments, and resource assessment data, BiOpt optimizes resource distributions across ...
Nicholas A. Carlson, Emily K. Newes, Kristen Lu, Eric C. D. Tan   +3 more
wiley   +1 more source

Clinical evaluation of the golden beam data in the monaco treatment planning system for the harmony pro and infinity linear accelerators. [PDF]

J Appl Clin Med Phys
Gao W, Zhang M, Zhang S, Qi J, Wang X, Zhao L, Liu P, Yang Z, Cheng H.   +8 more
europepmc   +1 more source

A phase 1 study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of PF‐07261271 in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Aim There is an unmet need for more effective therapies in inflammatory bowel disease (IBD). A single drug that blocks multiple distinct pathogenic pathways may offer therapeutic benefit superior to current monotherapies. PF‐07261271, a bispecific antibody targeting both the p40 subunit of interleukin‐12/23 and tumour necrosis factor‐like cytokine 1A ...
Srividya Neelakantan, Christopher Banfield, Kenneth Hung, Anna Sapone, Vivek Pradhan, Yuxi Zhao, Dana Parsons‐Rich, Grace Lee, Bryce G. Johnson, Elena Peeva, Michael S. Vincent, Valerie M. Clerin   +11 more
wiley   +1 more source

Evaluation of the Effect of Food and Formulation on the Pharmacokinetics of the SHP2 Inhibitor Migoprotafib Within a Phase I Study in Cancer Patients. [PDF]

Clin Transl Sci
Suchomel J, Bowman CM, Chiang PC, Dhawan M, Eng-Wong J, Hauser P, Johnson R, Muliadi AR, Pisupati S, Ramakrishnan V, Wagner L, Mandlekar SV.   +11 more
europepmc   +1 more source

Nicotinamide Reverses the Warburg Effect in CHO Cell Culture

Biotechnology and Bioengineering, EarlyView.
Abstract The Warburg effect, the preferential conversion of glucose‐derived pyruvat to lactate despite available oxygen, is a key feature of Chinese hamster ovary (CHO) cell culture. Lactate accumulation in recombinant protein‐producing cell culture is an inefficient usage of glucose, as well as being deleterious to cells.
James Morrissey, Ayca Cankorur‐Cetinkaya, Luigi Grassi, Annie J. Harwood‐Stamper, Jonathan Welsh, Ryte Poskute, Kasia Kozakowska‐McDonnell, Cleo Kontoravdi   +7 more
wiley   +1 more source

Pharmacokinetic Comparability of ABP 654, a Biosimilar to Ustekinumab, Administered Either via Prefilled Syringe or Autoinjector in Healthy Adults: Results from a Randomized, Open-Label, Parallel-Group Study. [PDF]

Clin Pharmacol Drug Dev
Chow V, Winkle PJ, Mytych DT, Cao J, Barragan C, Colbert A, Gupta S, Radziszewski W, Franklin J.   +8 more
europepmc   +1 more source

Click Before You Pipette: Building Foundational Pipetting Skills and Confidence With an Interactive Prelaboratory Simulation

Biochemistry and Molecular Biology Education, EarlyView.
ABSTRACT Correctly setting and reading a manual air displacement micropipette is an essential yet challenging skill for life‐science students. The incorrect delivery of volumes affects both experimental outcomes and data interpretation, potentially reducing student confidence in the laboratory.
Maurizio Costabile, Beth Loveys
wiley   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source