Results 61 to 70 of about 12,828 (263)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
The Logic of Contingent Actuality
Ergo, An Open Access Journal of PhilosophyCurrent orthodoxy in modal logic and metaphysics has it that actuality is non-contingent in the following sense: for all p, if actually, p, then necessarily, actually, p. Call this thesis (Actuality) Necessitism and its negation (Actuality) Contingentism.
Martin Glazier, Stephan Krämer
doaj +2 more sources
Danica Andrejević, the interpreter of the recent Kosovo-Metohian literature [PDF]
Baština, 2013 One of the rare interpreter and preserver of the modern literary creativity of the Serbs in Kosovo and Metohia, Danica Andrejević, via her texts, monograph publications, lexicons and anthologies, has been systematizing and situating this literature for ...
Denić Sunčica
doaj
Erkenntnis, 2009 It is known that indicative and subjunctive conditionals interact differently with a rigidifying “actually” operator. The paper studies this difference in an abstract setting. It does not assume the framework of possible world semantics, characterizing “actually” instead by the type of logically valid formulas to which it gives rise.
openaire +3 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The alleged activity of active intellect: A wild goose chase or a puzzle to be solved?
Zagadnienia Filozoficzne w Nauce, 2014 Trying to describe the activity of Aristotle’s active intellect, we will sooner or later realize that we cannot find its right description, because Aristotle did not provide for one.
Sonia Kamińska
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source