Results 41 to 50 of about 12,821 (263)
Actualism, Serious Actualism, and Quantified Modal Logic
Notre Dame Journal of Formal Logic, 2018 The paper navigates in the waters between metaphysical doctrine and formal logical representation. The goal is to build a first-order modal logic that accommodates both ``actualism'' (the view there are no merely possible things, that is, things that do not exist but have some alternative kind of being) and ``serious actualism'' (that all sentences ...
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Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Course of Actualization [PDF]
Language, 2012 Actualization is traditionally seen as the process following syntactic reanalysis whereby an item’s new syntactic status manifests itself in new syntactic behavior. The process is gradual in that some new uses of the reanalyzed item appear earlier or more readily than others.
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
“Robotics – History and Actuality” Workshop [PDF]
Robotica & Management, 2023 An important and interesting event in the field of Robotics occured in Reşiţa, Romania, on June the 8th. From 12:00 p.m. to 2:00 p.m., the workshop with the theme "Robotics - history and actuality" took place in room A.2.2 of the BBU University Center in
Ion Vela +3 more
doaj
New Actualism; Is the New Actualism a Kind of the Proxy Actualism?
حکمت و فلسفه, 2009 Actualism is an ontological thesis according to which the domain of existent objects and the domain of actual ones are the same. According to this thesis, we do not need to commit to any non-actual objects for solving any philosophical problems. The approach of Bernard Linsky, Edward N.
lotfollah nabavi, mojtaba amir khanluo
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FEBS Open Bio, EarlyView.A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source