Results 51 to 60 of about 206,790 (331)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Explaining A Narrative in The Critical Philosophy of History
Jurnal Filsafat, 2019 This paper explains the narrative in the study of history which has only been understood as a way of telling what should have happened, not what really happened.
Arif Akhyat
doaj +1 more source
Acta Universitatis Carolinae Theologica, 2022 Bonaventure’s epistemology is partly based on his Trinitarian theology. This paper investigates the Trinitarian connotations in this epistemology and their broader significance.
Jonathan Bieler
doaj +1 more source
Panpsychism: Ubiquitous Sentience [PDF]
, 2018 This public article presents three arguments for the plausibility of panpsychism: the view that sentience is a fundamental and ubiquitous element of actuality. Thereafter is presented a brief exploration of why panpsychism has been spurned. The
Sjöstedt-H., Peter
core
Epistemicism and modality [PDF]
, 2016 What kind of semantics should someone who accepts the epistemicist theory of vagueness defended in Timothy Williamson’s Vagueness (1994) give a definiteness operator?
Yli-Vakkuri, Juhani
core +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
ReligionsI will consider, first, the positive charge of energeia in Aristotle, who identified it with the actuality of the actual. Then, I will pay attention to the negative charge that re-signifies the term, bestowing on it the exact opposite sense of ...
Michael Marder
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
The alleged activity of active intellect: A wild goose chase or a puzzle to be solved?
Zagadnienia Filozoficzne w Nauce, 2014 Trying to describe the activity of Aristotle’s active intellect, we will sooner or later realize that we cannot find its right description, because Aristotle did not provide for one.
Sonia Kamińska
doaj
El arte de lo posible: La Historia de la Educación como práctica radical
Historia y Memoria de la EducaciónEste ensayo pretende demostrar cómo el pensamiento ecológico, a través de una lectura parcial de la obra de Walter Benjamin, podría ofrecer una base sólida para integrar la historia pública, la investigación artística y el activismo en la historia de la
Angelo Van Gorp
doaj +1 more source