Results 31 to 40 of about 28,487 (304)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

Queue de renard, ficelle et plume : classer sa bibliothèque

open access: yesArts et Savoirs, 2018
Through the study of personal papers, it is understood that L’Estoile meticulously classified the books in his library. This classification sheds light on the collection’s history as well as the many relationships between L’Estoile himself and his ...
Gilbert Schrenck
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

İbn Sînâ’da Kuvve-Fiil Teorisi

open access: yesBozok Üniversitesi İlahiyat Fakültesi Dergisi
Bu çalışma felsefenin temel konularından birisi olan kuvve-fiil teorisi hakkındadır ve bu yüzden önem arz etmektedir. Felsefî bir izah yöntemi olması açısından kuvve-fiil teorisi tanınmakta ve oldukça işe yaramaktadır.
Fevzi Yiğit
doaj   +1 more source

Arystotelesa charakterystyka zniszczalnych substancji (Aristotle’s Characteristic of the Sensible and Destructible Substances) [PDF]

open access: yesAnaliza i Egzystencja, 2011
The present article attempts to explain what Aristotle’s sensible and destructiblesubstance is from the viewpoint of their separability (to choriston) and individuality(to tode ti).
Maciej Smolak
doaj  

To Repeat or Not To Repeat: That is the Question

open access: yesPerformance Philosophy, 2017
I had never been in Copenhagen before, yet this was my second visit to the city. The purpose of my travel was to inhabit, at least for several days, the urban environment that once contained the peripatetic musings of Søren Kierkegaard. I went to Denmark’
Leo Cabranes-Grant
doaj   +1 more source

Sittlichkeit and the Actuality of Freedom:On Kant and Hegel [PDF]

open access: yes, 2020
The relationship between Hegel’s conception of Sittlichkeit and Kant’s moral philosophy is much-discussed, highly controversial and accompanied by many misunderstandings.
Christian Krijnen   +1 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

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