Results 211 to 220 of about 84,534 (351)

Pyroptosis in Peripheral Neuropathy: From Molecular Mechanisms to Therapeutic Targeting

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Pyroptosis is a key inflammatory cell death pathway in peripheral neuropathy, with opposing roles: it perpetuates neuropathic pain but can be induced to kill neuroblastoma cells. This review consolidates mechanistic understanding and therapeutic strategies, arguing for a shift from disease‐centric to target‐centric treatment approaches to improve ...
Jinhuan Wei   +11 more
wiley   +1 more source

Nonsteroidal Anti‐Inflammatory Drugs and Risk of Gastrointestinal Bleeding: A Systematic Review and Meta‐Analysis

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 46-62, January 2026.
Nonsteroidal anti‐inflammatory drugs (NSAIDs) are widely used for pain and inflammation but are associated with gastrointestinal (GI) bleeding. While this risk is well established, most studies evaluate NSAIDs as a homogenous class, limiting clinical decision‐making based on individual agent safety.
Abdelrahman G. Tawfik   +7 more
wiley   +1 more source

Assessing the Impact of Interdisciplinary Multimodal Pain Treatment on Health‐Related Quality of Life in Chronic Pain: A Systematic Review and Meta‐Analyses

open access: yesEuropean Journal of Pain, Volume 30, Issue 1, January 2026.
ABSTRACT Background and Objective Chronic pain lowers health‐related quality of life (HRQoL). This review presents the most complete examination to date of how Interdisciplinary Multimodal Pain Treatment (IMPT) affects domains of HRQoL in adults with chronic pain. We compared IMPT with treatment as usual (TAU) and active control groups (ACGs) at short,
Alistair Turvill   +2 more
wiley   +1 more source

Frozen Shoulder Is More Than Local Pain: Widespread Sensory Hyperalgesia or Hypoesthesia?

open access: yesEuropean Journal of Pain, Volume 30, Issue 1, January 2026.
ABSTRACT Background Frozen shoulder (FS) has long been considered a localised musculoskeletal disorder, yet FS often involves widespread pain, suggesting central sensory dysregulation. While pressure pain threshold (PPT) assesses mechanical sensitivity, electrical measures such as current perception threshold (CPT) and electrical pain threshold (EPT ...
Shiya Yu   +6 more
wiley   +1 more source

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