Results 71 to 80 of about 3,859,259 (322)

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

"It's Sink or Swim'': Exploring Patients' Challenges and Tool Needs for Self-Management of Postoperative Acute Pain [PDF]

Poorly managed postoperative acute pain can have long-lasting negative impacts and pose a major healthcare issue. There is limited investigation to understand and address the unique needs of patients experiencing acute pain. In this paper, we tackle this gap through an interview study with 14 patients who recently underwent postoperative acute pain to ...
arxiv   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Acute Appendicitis

The Moldovan Medical Journal, 2018
Background: It has been more than 130 years since Reginald Fitz described for the first time the pathomorphological changes of the acute appendicitis and after the first appendectomy that was performed by H. Hancock, in the case of acute appendicitis, but the problem remains to be actual till now.
Bazeliuc, Iurii, Gugava, Vahtang, Bour, Alin   +2 more
openaire   +4 more sources

Proton pump inhibitor-induced Sweet’s syndrome: report of acute febrile neutrophilic dermatosis in a woman with recurrent breast cancer

Dermatology Practical & Conceptual, 2015
Background: Sweet’s syndrome, also referred to as acute febrile neutrophilic dermatosis, can either occur as an idiopathic disorder or associated with another condition, including cancer, or induced by exposure to a drug.
Philip R. Cohen
doaj   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Frecuencia de abdomen agudo quirúrgico en pacientes que consultan al servicio de urgencias Frequency of acute surgical abdomen in patients consulting the emergency service

Revista Colombiana de Cirugía, 2011
Introducción. El dolor abdominal es una causa frecuente de consulta en los servicios de urgencias, y compete a todo médico conocer a fondo sus características para determinar rápidamente la conducta que se debe seguir, dado que de su oportuna decisión ...
Mónica Bejarano, Cristal Ximena Gallego, Julián Ricardo Gómez   +2 more
doaj  

Virtual monochromatic imaging in dual-source and dual-energy CT for visualization of acute ischemic stroke [PDF]

arXiv, 2015
We have recently developed a phantom that simulates acute ischemic stroke. We attempted to visualize acute-stage cerebral infarction by applying virtual monochromatic images to this phantom using dual-energy CT (DECT). Virtual monochromatic images were created using DECT from 40 to 100 keV at every 10 keV and from 60 to 80 keV at every 1 keV, under ...
arxiv  

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

On Point Sets in Vector Spaces over Finite Fields That Determine Only Acute Angle Triangles [PDF]

arXiv, 2009
For three points $\vec{u}$,$\vec{v}$ and $\vec{w}$ in the $n$-dimensional space $\F_q^n$ over the finite field $\F_q$ of $q$ elements we give a natural interpretation of an acute angle triangle defined by this points. We obtain an upper bound on the size of a set $\cZ$ such that all triples of distinct points $\vec{u}, \vec{v}, \vec{w} \in \cZ$ define ...
arxiv