Results 141 to 150 of about 1,906,242 (299)

Loss of POGLUT2/3‐mediated O‐glucosylation produces lung and aortic phenotypes reminiscent of fibrillin1 mutants

Developmental Dynamics, EarlyView.
Abstract Background Fibrillins provide a scaffold for elastic fiber formation, which enables lung recoil and aortic compliance. Abnormal fibrillin microfibrils, as in Marfan syndrome, lead to enlarged alveoli, vascular stiffening, and aneurysms. Our earlier studies suggested that fibrillin function depends on O‐glucosylation of its epidermal growth ...
Sanjiv Neupane, Angelina Almiroudis, Kaitlyn E. Donnelly, Robert S. Haltiwanger, Bernadette C. Holdener   +4 more
wiley   +1 more source

Quality of life after acute type B dissection in the era of thoracic endovascular aortic repair

, 2010
Conservative management of acute type B aortic dissection is currently being challenged by primary thoracic endovascular aortic repair. Aim was to assess outcome and quality of life after these different approaches using an adjusted standard population ...
Carrel, T P, Schmidli, J, Immer, Franz F, Hinder, D, Dick, F, Dai-Do, D, Hirzel, C, Hinder D, Hirzel C, Dai-Do D, Immer FF, Dick, Florian, Schmidli, Jürg, Dick F, Carrel, Thierry, Carrel TP, Schmidli J   +16 more
core   +1 more source

Hemodynamic loading regulates formation and patterning of atrial pectinate muscles in the chick embryo

Developmental Dynamics, EarlyView.
Development and differentiation of the atrial myocardium. Hemodynamic loading triggers shear stress response, which is essential for pectinate muscle formation; mechanical stretching is important for the expression of chamber myocardium markers and proper maturation of the atrial contractile and conductive properties.
C. Neradilova, K. Neffeova, A. Kvasilova, B. Sankova, F. Vostarek, M. Bartos, H. Kolesova, D. Sedmera   +7 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Incidence, presentation and outcome of acute aortic dissection: results from a population-based study

Open Heart
Objectives To describe the incidence of acute aortic dissection in a clearly defined population, to assess onset symptoms and admission biochemical marker levels and to analyse variables potentially associated to mortality.Methods Medical records and CT ...
Johnny Steuer, Rebecka Hultgren, Christian Olsson, Christian Smedberg   +3 more
doaj   +1 more source

Suspected Mesenteric Malperfusion in Acute Type A Aortic Dissection During Pregnancy: A Case Report and Review of Reperfusion‐First Strategies

Clinical Case Reports
Aortic dissection during pregnancy is rare but potentially catastrophic. Acute Type A aortic dissection generally requires urgent surgical repair. When visceral malperfusion is present, however, the optimal sequence of interventions may be complex ...
Tam Le, Steven Chok, Khuram Khan
doaj   +1 more source

Transendocardial injection of expanded autologous CD34+ cells after myocardial infarction: Design of the EXCELLENT trial

ESC Heart Failure, Volume 12, Issue 2, Page 1455-1463, April 2025.
Abstract Aims The extent of irreversible cardiomyocyte necrosis after acute myocardial infarction (AMI) is a major determinant of residual left ventricular (LV) function and clinical outcome. Cell therapy based on CD34+ cells has emerged as an option to help repair the myocardium and to improve outcomes.
Jerome Roncalli, François Roubille, Nicolas Meyer, Giulio Pompilio, Lionel Leroux, Philippe Henon, Guillaume Trebuchet, Anthony Criquet, Matthieu de Kalbermatten, Eric Saloux, Alain Manrique, Pierre‐Yves Marie, Deepak L. Bhatt, Scott D. Solomon, Gilles Montalescot, David E. Newby, Faiez Zannad, on behalf of the EXCELLENT Trial Investigators   +17 more
wiley   +1 more source

Strategies for subacute/chronic type B aortic dissection: the Investigation Of Stent Grafts in Patients with type B Aortic Dissection (INSTEAD) trial 1-year outcome

, 2010
Endovascular stent grafting represents a novel concept for type B aortic dissection both in the acute and subacute/chronic setting, with an unknown effect on ...
Kleinfeldt, Tilo, Rehders, Tim C, Fattori, Rossella, Guenther Kundt, Ibrahim Akin, Louis Labrousse, Rousseau, Hervé, Ince, Hüseyin, Stephan Kische, Tilo Kleinfeldt, Burkhart Zipfel, Martin Czerny, Scheinert, Dierk, Hervé Rousseau, Nienaber, Christoph A, Czerny, Martin, Christoph A. Nienaber, Zipfel, Burkhart, Holger Eggebrecht, Tim C. Rehders, Hüseyin Ince, Rossella Fattori, Labrousse, Louis, Eggebrecht, Holger, Kundt, Guenther, Dierk Scheinert, Kische, Stephan, Akin, Ibrahim   +27 more
core   +1 more source

CardiLect: A combined cross‐species lectin histochemistry protocol for the automated analysis of cardiac remodelling

ESC Heart Failure, Volume 12, Issue 2, Page 1398-1415, April 2025.
Abstract Background Cardiac remodelling, a crucial aspect of heart failure, is commonly investigated in preclinical models by quantifying cardiomyocyte cross‐sectional area (CSA) and microvascular density (MVD) via histological methods, such as immunohistochemistry.
Tamás G. Gergely, Tamás Kovács, Andrea Kovács, Viktória E. Tóth, Nabil V. Sayour, Gábor M. Mórotz, Csenger Kovácsházi, Gábor B. Brenner, Zsófia Onódi, Balázs Enyedi, Domokos Máthé, Przemyslaw Leszek, Zoltán Giricz, Péter Ferdinandy, Zoltán V. Varga   +14 more
wiley   +1 more source

Water‐driven dispersible fiber electrode arrays for position‐dependent intracardiac electrophysiological recording

FlexMat, EarlyView.
Abstract Intracardiac electrophysiological recording plays an essential role in identifying abnormal cardiac electrical activity and guiding arrhythmia diagnosis and treatment planning. A key challenge for minimally invasive intracardiac electrodes is to combine reliable transvascular delivery with stable and compliant endocardial contact.
Jinyang Mao, Hangyu Li, Yuehui Yuan, Zixuan Chen, Shihan Xu, Ming Chu, Minglong Chen, Benhui Hu   +7 more
wiley   +1 more source