Results 41 to 50 of about 60,809 (218)

Debate: When should we intervene in unstable angina - Time for an old look?

Current Controlled Trials in Cardiovascular Medicine, 2000
Current treatment modalities for patients with acute coronary syndromes center on early diagnosis, risk stratification and, increasingly, early treatment including invasive approaches. The appropriate timing of these invasive modalities in the context of
Laskey Warren K
doaj   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source

Inflammation Unchecked: Concurrent Kawasaki Disease and Stevens‐Johnson Syndrome in an 18‐Month‐Old Child

Arthritis Care &Research, EarlyView.
Catherine Deffendall, Jodi Backalar, Elizabeth Acevedo Zapata, Adriana Della Porta, Lorin Bibb, Tyler Reese, Charlotte M. Brown   +6 more
wiley   +1 more source

A Hybrid Hierarchical Framework for Quantifying Mechanical Markers in Atherosclerotic Disease Progression: A New Approach for Diagnosis and Risk Assessment

Advanced Science, EarlyView.
The mechanobiological basis of atherosclerotic progression and its contribution to spatial and temporal heterogeneity remain incompletely understood. Spatially resolved AFM measurements revealed that plaque formation and distinct regions (cap fibrosis, intimal fibrosis, and lipid‐rich core) exhibit heterogeneous elastic modulus and viscoelastic ...
Yidan Zhou, Zhuo Chang, Xianjun Wu, Sijie Wang, Yuzhi Zhang, Hao Zhang, Haoyu Xu, Ruining Peng, Zhe Wang, Huiyun Xu, Yu Liu, Guangkui Xu, Nu Zhang, Hui Yang   +13 more
wiley   +1 more source

Relationship of Platelet Reactivity With Bleeding Outcomes During Long‐Term Treatment With Dual Antiplatelet Therapy for Medically Managed Patients With Non‐ST‐Segment Elevation Acute Coronary Syndromes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundThe relationship between “on‐treatment” low platelet reactivity and longitudinal risks of major bleeding dual antiplatelet therapy following acute coronary syndromes remains uncertain, especially for patients who do not undergo percutaneous ...
Jan H. Cornel, E. Magnus Ohman, Benjamin Neely, Joseph A. Jakubowski, Deepak L. Bhatt, Harvey D. White, Diego Ardissino, Keith A.A. Fox, Dorairaj Prabhakaran, Paul W. Armstrong, David Erlinge, Udaya S. Tantry, Paul A. Gurbel, Matthew T. Roe   +13 more
doaj   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Relapsing Polychondritis-Associated Myocardial Infarction With Non-Obstructive Coronary Arteries

Journal of Investigative Medicine High Impact Case Reports
We describe a 40-year-old South Asian female with relapsing polychondritis-associated myocardial infarction with non-obstructive coronary arteries during an acute flare for which she was successfully managed with guideline-directed medical therapy.
Narine Mack MBBS, Arun Katwaroo MBBS, Matthew Maharaj MBBS, Ryan Ramdin MBBS, Priya Ramcharan MBBS, Valmiki Seecheran MBBS, MSc, Rajeev Seecheran MBBS, MHA, Neal Bhagwandass MBBS, MSc, Naveen Seecheran MBBS, MSc   +8 more
doaj   +1 more source

Adhesion Molecules and Vulnerable Plaques – Promoters of Acute Coronary Syndromes

Journal of Cardiovascular Emergencies, 2022
Biological factors that characterize extrinsic plaque vulnerability include various pro- and anti-inflammatory cytokines that contribute to the development and progression of atherosclerosis.
Opincariu Diana, Benedek Theodora
doaj   +1 more source

Heterozygous Variants in LRP1 Cause a Neurodevelopmental Disorder With Congenital Heart Defects

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT LRP1 encodes the low‐density lipoprotein (LDL) receptor‐related protein 1 (LRP1), a transmembrane protein involved in endocytosis and activation of multiple signaling pathways. LRP1 variants have been implicated in the pathogenesis of congenital heart defects (CHD), Alzheimer's disease, and neurodevelopmental disorders (NDD).
Alyssa L. Rippert, Gudny Anna Arnadottir, Laura Bedinger, Nicola Brunetti‐Pierri, Jennifer Cech, Xin Chen, Yanmin Chen, Erika Chick, Sarah Dyack, Madeleine Franchi, Tanja Frey, David Genevieve, Ian Glass, Jorge Granadillo, Kelly A. Keener, Sara B. MacKay, Paige McDunnah, Vinod K. Misra, Kristin G. Monaghan, Sureni V. Mullegama, Cristina Peduto, Leia Peterman‐Prather, Anita Rauch, Cherith Somerville, Kari Stefansson, Katharina Steindl, Patrick Sulem, Telma Sulem, Pamela Trapane, Roberta Zeuli, Samuel Zinner, Kosuke Izumi   +31 more
wiley   +1 more source

Unveiling the Causes of Acute and Non-Acute Myocardial Ischemic Syndromes: The Role of Optical Coherence Tomography

Medicina
Despite significant advances in understanding and management, cardiovascular diseases remain the leading cause of mortality worldwide. Historically, diagnostic and therapeutic strategies have typically targeted obstructive coronary arteries.
Angela Buonpane, Alberto Ranieri De Caterina, Giancarlo Trimarchi, Francesca Maria Di Muro, Domenico Galante, Samuela Zella, Fausto Pizzino, Marco Ciardetti, Umberto Paradossi, Giovanni Concistrè, Sergio Berti, Antonio Maria Leone, Filippo Crea, Carlo Trani, Francesco Burzotta   +14 more
doaj   +1 more source