Results 101 to 110 of about 29,694 (216)

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

SARS‐CoV‐2 targets mitochondria, exacerbating COVID‐19 pneumonia

The Journal of Physiology, EarlyView.
Abstract figure legend Following entry into airway epithelial cells (AECs), SARS‐CoV‐2 releases its single‐stranded RNA into the cytoplasm, where it is translated into viral proteins. Several of these viral proteins localize to mitochondria and interact with key mitochondrial components.
Danchen Wu, Asish Dasgupta, Jaskaran Singh Hora, Kuang‐Hueih Chen, Arinjay Banerjee, Stephen L. Archer   +5 more
wiley   +1 more source

Initial Experience With Endoscopic Ultrasound‐Guided Gallbladder Drainage Using Lumen‐apposing Metal Stents in Extremely Elderly and Frail Patients

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Objectives Endoscopic ultrasound‐guided gallbladder drainage (EUS‐GBD) using lumen‐apposing metal stents (LAMS) is a treatment option for acute cholecystitis in high‐risk surgical patients. However, data on extremely elderly and frail patients are limited. We report our initial experience with EUS‐GBD using electrocautery‐enhanced LAMS in this
Kiyoyuki Kobayashi, Takako Nomura, Maki Ayaki, Tomohiro Ogi, Yudai Sato, Manabu Yamada, Daisuke Namima, Naoki Fujita, Hiroki Yamana, Hideki Kamada, Toshiharu Funaki, Akihiro Kondo, Yasuhisa Ando, Hironobu Suto, Minoru Oshima, Keiichi Okano, Hideki Kobara   +16 more
wiley   +1 more source

Desired and Feared Identities and Their Role in Occupational Identity Regulation

Journal of Management Studies, Volume 63, Issue 6, Page 2927-2964, September 2026.
Abstract This paper extends theory by showing how occupational identity regulation operates jointly through both desired and feared identities which, in combination, enforce normative control. Taking a narrative identity perspective and drawing on an ethnographic and interview‐based study of veterinarians, we make three principal contributions to our ...
Sarah Page‐Jones, Andrew D. Brown
wiley   +1 more source

Prognosis of Long‐Term Continuous Renal Replacement Therapy and the Impact of Combined Continuous Intravenous Sodium Infusion Therapy

Therapeutic Apheresis and Dialysis, Volume 30, Issue 4, Page 460-470, August 2026.
ABSTRACT Introduction Patients requiring long‐term continuous renal replacement therapy (CRRT) generally have poor prognoses. This study evaluated whether adding continuous intravenous sodium infusion (cIVNa) is associated with improved hemodynamics and outcomes in patients undergoing long‐term CRRT for ≥ 7 days.
Akinori Yamaguchi, Atsuyoshi Mita, Kosuke Sonoda, Makoto Harada, Koji Hashimoto, Hiroshi Imamura, Yuji Kamijo   +6 more
wiley   +1 more source

Vitamin B3 (Nicotinamide) Supplementation in Primary and Scleroderma‐Related Raynaud Phenomenon

ACR Open Rheumatology, Volume 8, Issue 8, August 2026.
Objective The aim of this study was to explore if vitamin B3 (nicotinamide) supplementation is a safe and effective adjunctive therapy for patients with primary Raynaud phenomenon (RP) and scleroderma‐related RP. The effect of nicotinamide supplementation in human patients with RP has not been studied before.
Mogeshni Govender, Natalie Tomson, Johnny Fang, Mohamed Bakry, Raymond Liu, Kathleen Morrisroe, Ross Penglase, Kokum Dissanayake, Ted Tsai   +8 more
wiley   +1 more source

Infective Endocarditis Diagnosed by Emergency Physicians Using Cardiac POCUS: A Case Series

Australasian Journal of Ultrasound in Medicine, Volume 29, Issue 3, August 2026.
ABSTRACT Introduction Emergency physicians (EPs) are acquiring ever‐increasing expertise in cardiac point‐of‐care ultrasound (POCUS). We compiled this case series to demonstrate current practice by EPs diagnosing infective endocarditis (IE) using POCUS.
Jonathan Henry, Mark Rugless, Claudiu Radeanu, Abrar Waliuddin, Kevin Phang, Allan Whitehead, Shanu Khader, David Henry, Darsim Haji   +8 more
wiley   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2723-2740, August 2026.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

External validation of the BAN‐ADHF diuretic‐resistance score in the DAPA‐RESIST clinical trial

British Journal of Clinical Pharmacology, Volume 92, Issue 8, Page 2960-2965, August 2026.
Diuretic resistance in worsening heart failure (HF) is associated with poorer outcomes and, although common, can be challenging to identify. The recently developed BAN‐ADHF score can potentially identify patients with worsening HF at risk of diuretic resistance.
Dominic M. Alfonso, Kieran F. Docherty, Matthew M. Y. Lee, Patrick B. Mark, Alex McConnachie, Joanna Osmanska, Bethany Stanley, Atefeh Talebi, Mark C. Petrie, John J. V. McMurray, Ross T. Campbell   +10 more
wiley   +1 more source

A Comprehensive and Critical Evaluation of Autonomic Nervous System Impairment in Patients with Wilson Disease: A Cross‐Sectional Study

Brain and Behavior, Volume 16, Issue 8, August 2026.
ABSTRACT Background Wilson's disease (WD) is an autosomal recessive disorder of copper metabolism with heterogeneous hepatic and neurological manifestations. Autonomic nervous system (ANS) involvement in WD is poorly recognized and remains inadequately studied, despite its potential to cause significant morbidity if unrecognized.
Sabyasachi Pattanayak, Niraj Kumar Srivastava, Anand Kumar, Deepika Joshi, Atanu Roy, Sanjeev Kumar Singh, Rajniti Prasad, Suyash Tripathi, Ashish Verma, Ritu Ojha, Varun Kumar Singh, Abhishek Pathak, Rameshwar Nath Chaurasia, Vijaya Nath Mishra, Ibrahim Hussain   +14 more
wiley   +1 more source