Results 71 to 80 of about 1,507,605 (275)

Extrahepatic Surgery in Cirrhosis Significantly Increases Portal Pressure in Preclinical Animal Models

Frontiers in Physiology, 2021
Background: Liver cirrhosis is a relevant comorbidity with increasing prevalence. Postoperative decompensation and development of complications in patients with cirrhosis remains a frequent clinical problem.
Johannes Chang, Jonathan Meinke, Moritz Geck, Marc Hebest, Nina Böhling, Ramona Dolscheid-Pommerich, Birgit Stoffel-Wagner, Glen Kristiansen, Marcus Overhaus, Leon O. Peyman, Sabine Klein, Frank E. Uschner, Maximilian J. Brol, Tim O. Vilz, Philipp Lingohr, Jörg C. Kalff, Christian Jansen, Christian P. Strassburg, Sven Wehner, Jonel Trebicka, Jonel Trebicka, Michael Praktiknjo   +21 more
doaj   +1 more source

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source

Baseline podocyte‐associated state and persistent cell–matrix transcriptional programs are associated with BALB/c substrain differences in adriamycin nephropathy

Animal Models and Experimental Medicine, EarlyView.
Two closely related BALB/c substrains exhibit different early responses to adriamycin (ADR)‐induced nephropathy. BALB/cByJcl mice showed lower baseline WT1‐positive nuclei counts and NPHS1 immunoreactivity than BALB/cAJcl mice, together with extracellular matrix and integrin programs that were enriched at baseline and persisted at Day 5.
Ryuya Nakagawa, Masaki Watanabe, Koyuki Kawamoto, Momoka Hiratsuka, Takeru Sasaki, Nobuya Sasaki   +5 more
wiley   +1 more source

The Value of Neutrophil-to-Lymphocyte Ratio to Identify Bacterial Infection and Predict Short-Term Mortality in Patients with Acutely Decompensated Cirrhosis

Diagnostics, 2023
Liver cirrhosis patients are highly susceptible to infections, affecting survival, but current parameters for detecting infection are not reliable enough in this population.
Tamás Janka, Dávid Tornai, Mária Papp, Zsuzsanna Vitális   +3 more
doaj   +1 more source

Patient characteristics stratified by survivors or non-survivors at day 28 and day 90 in cases with acute decompensation.

, 2022
Patient characteristics stratified by survivors or non-survivors at day 28 and day 90 in cases with acute decompensation.
Kazufumi Kobayashi (12009479), Masayuki Ohtsuka (10098637), Satoshi Kuboki (378666), Yoshihiko Ooka (508760), Sadahisa Ogasawara (508759), Shingo Nakamoto (337728), Keisuke Koroki (12009473), Naoya Kato (134988), Takayuki Kondo (6182219), Jun Kato (649096), Hiroaki Kanzaki (12009476), Tomoko Saito (585310), Tetsuhiro Chiba (508754), Makoto Arai (3811165), Soichiro Kiyono (12009482), Naoya Kanogawa (731173), Masato Nakamura (47969)   +16 more
core   +1 more source

Toward a Behavioral Reserve Model in Amyotrophic Lateral Sclerosis

Annals of Neurology, EarlyView.
Objective Behavioral impairment is common in amyotrophic lateral sclerosis (ALS) and strongly affects autonomy, caregiver burden, and outcomes, yet predictors of vulnerability remain unclear. We investigated whether premorbid regulatory traits and socio‐educational exposures are associated with behavioral phenotypes in ALS within a behavioral reserve ...
Francesca Palumbo, Barbara Iazzolino, Cristina Moglia, Umberto Manera, Enrico Matteoni, Sara Cabras, Giorgio Pellegrino, Emilio Minerva, Vita Passidomo, Rosario Vasta, Gabriele Mora, Fabrizio D’Ovidio, Antonio Canosa, Andrea Calvo, Adriano Chiò   +14 more
wiley   +1 more source

Clinical clusters during acute illness predict long-term mortality in older patients

BMC Medicine
Background Defining acute illness decompensation as a single entity limits individualisation of treatments for older patients. Multi-modal and high-dimensional data offer opportunities to derive quantified clusters with clinically meaningful outcomes. We
A. Tsui, P. Hogan, H. Cheston, O. Dunne, D. Gardner, A. McWhirter, L. M. Allan, S. Richardson, P. Nachev, D. Davis   +9 more
doaj   +1 more source

Acute decompensation events differentially impact the risk of nosocomial infections and short-term outcomes in patients with cirrhosis

Frontiers in Medicine, 2022
AimsThis research aimed to evaluate the influence of acute decompensation (AD) events upon admission on the subsequent risk of nosocomial infections (NIs) and the synergy between AD and the following NIs on the short-term outcome.MethodsA total of 419 ...
Xianbin Xu, Xia Yu, Kai Gong, Huilan Tu, Junjie Yao, Yan Lan, Shaoheng Ye, Haoda Weng, Yu Shi, Jifang Sheng   +9 more
doaj   +1 more source

Prediction of Acute Liver Injury Trajectory in Patients Following Acetaminophen Overdose: A Multibiomarker Machine Learning Proof‐of‐Concept Study

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical translation of novel therapies can be hindered by heterogeneity‐driven sample size inflation in late‐stage trials. In acetaminophen‐induced liver injury (APAP DILI), many patients recover spontaneously, diluting investigational drug efficacy signals.
Chris Humphries, Alastair M. Kilpatrick, Kathleen M. Scullion, Rhona Aird, Lorraine Bruce, Maria Elena Candela, Tak Yung Man, Stuart J. Forbes, James W. Dear   +8 more
wiley   +1 more source

Outpatient treatment of decompensated heart failure: A systematic review and study level meta‐analysis

ESC Heart Failure, Volume 12, Issue 2, Page 761-769, April 2025.
Abstract Patients with acutely decompensated heart failure (ADHF) are usually admitted to hospital for management. There is growing interest in delivering intravenous (IV) diuretic therapy at home, in the community or at hospital day‐care units; the safety and effectiveness of outpatient‐based management (OPM) for ADHF has not been established.
Jameela Bahar, Amna Rahman, Grace W.Y. Wong, Rajiv Sankaranarayanan, Fozia Z. Ahmed, Rebecca Taylor, Ahmet Fuat, Iain Squire, John G.F. Cleland, Gregory Y.H. Lip, James H.P. Gamble, Sundas Masudi, Prince Josiah S. Joseph, Kenneth Y.K. Wong   +13 more
wiley   +1 more source