Results 141 to 150 of about 2,457,521 (267)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Extracorporeal membrane oxygenation, acute kidney injury, fluid balance, and continuous renal replacement therapy: Acute Disease Quality Initiative (ADQI) and Extracorporeal Life Support Organization (ELSO) joint consensus conference. [PDF]

Intensive Care Med
Gist KM, Selewski DT, Kashani KB, Akcan-Arikan A, Annich G, Antonini MV, Askenazi D, Awdishu L, Bridges BC, Connor MJ, Forni LG, Fuhrman DY, Goldstein SL, Gorga SM, Guru PK, Kaddourah A, Lepage-Farrell A, McMullan DM, Mehta RL, Menon S, Mottes T, Müeller T, Ostermann M, Paden ML, Rintoul NE, Reis T, Ronco C, See E, Singh G, Bagshaw SM, MacLaren G.   +30 more
europepmc   +1 more source

Mice infected with Mycobacterium tuberculosis are resistant to acute disease caused by secondary infection with SARS-CoV-2. [PDF]

PLoS Pathog, 2022
Rosas Mejia O, Gloag ES, Li J, Ruane-Foster M, Claeys TA, Farkas D, Wang SH, Farkas L, Xin G, Robinson RT, Robinson RT.   +10 more
europepmc   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Nipah Virus-Associated Neuropathology in African Green Monkeys During Acute Disease and Convalescence. [PDF]

J Infect Dis
Goldin K, Liu Y, Rosenke R, Prado-Smith J, Flagg M, de Wit E.   +5 more
europepmc   +1 more source

Neurographic Evidence of Inflammatory Polyneuropathies in Peri-COVID-19 Circumstances and Their Relationship With Acute Disease Severity and Inflammatory Storm. [PDF]

Cureus, 2022
Hasrat NH, Kadhum HJ, Hashim AR, Yakob ZA, Kadhim LA, Farid HA.   +5 more
europepmc   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Functional Capacity Impairment in Long COVID After 17 Months of Severe Acute Disease. [PDF]

Int J Environ Res Public Health
Borges FFDR, Braga ACB, Viana BS, Valente J, Bemfica JM, Sant'Anna T, Goulart CDL, Almeida-Val F, Arêas GPT.   +8 more
europepmc   +1 more source

Progressive Course of Chronic Tick-Borne Encephalitis Manifesting as Amyotrophic Lateral Sclerosis-like Syndrome 35 Years after the Acute Disease. [PDF]

Brain Sci, 2022
Volok VP, Gmyl LV, Belyaletdinova IK, Karganova GG, Dekonenko EP.   +4 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source