Results 211 to 220 of about 2,343,040 (267)
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo +7 more
wiley +1 more source
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
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Surgical Clinics of North America, 2018
Acute biliary disease is a ubiquitous acute surgical complaint. General surgeons managing emergency surgical patients must be knowledgeable and capable of identifying and caring for common presentations. This article discusses the work-up, diagnosis, and management of the varying pathologies that make up biliary disease including cholelithiasis ...
Ann Yih-Ann, Chung +1 more
openaire +2 more sources
Acute biliary disease is a ubiquitous acute surgical complaint. General surgeons managing emergency surgical patients must be knowledgeable and capable of identifying and caring for common presentations. This article discusses the work-up, diagnosis, and management of the varying pathologies that make up biliary disease including cholelithiasis ...
Ann Yih-Ann, Chung +1 more
openaire +2 more sources
Cocaine and Acute Vascular Diseases
Current Drug Abuse Reviewse, 2012Cocaine is one of the most widely used drugs of abuse. Chest pain is the most common side effect requiring emergency visits after cocaine use. Vasoconstriction and platelet activation are the main effects of cocaine in the vasculature. In this brief review, we consider the most important clinical effects of cocaine abuse on the heart, brain and kidney.
De Giorgi A. +9 more
openaire +2 more sources
The Management of Acute Hemorrhoidal Disease
Reviews on Recent Clinical Trials, 2021The acute strangulation of internal hemorrhoids and the thrombosis of external hemorrhoids are both debilitating and painful conditions which require immediate treatment in order to minimize morbidity and reduce the length of inactivity. In selected cases, urgent surgical treatment, performed within 72 hours of presentation, prevents the negative ...
Selvaggi, Lucio +4 more
openaire +3 more sources
Radiologic Clinics of North America, 1997
Acute hepatobiliary dysfunction in children may occur as the result of trauma, infectious hepatitis, biliary obstruction, benign and malignant tumors, and acute vascular obstruction. The targeted and integrated use of modern imaging techniques has made a significant impact in the diagnosis and management of these disorders.
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Acute hepatobiliary dysfunction in children may occur as the result of trauma, infectious hepatitis, biliary obstruction, benign and malignant tumors, and acute vascular obstruction. The targeted and integrated use of modern imaging techniques has made a significant impact in the diagnosis and management of these disorders.
openaire +2 more sources
Journal of the American Medical Association, 1954
In general, acute abdominal diseases are of four pathological types: obstructive, infectious, hemorrhagic, and vascular. Frequently a combination of these types is observed, as in obstructions incident to infection and inflammatory edema, and in hemorrhagic pancreatitis. Together, they may produce that most serious emergency: peritonitis.
openaire +2 more sources
In general, acute abdominal diseases are of four pathological types: obstructive, infectious, hemorrhagic, and vascular. Frequently a combination of these types is observed, as in obstructions incident to infection and inflammatory edema, and in hemorrhagic pancreatitis. Together, they may produce that most serious emergency: peritonitis.
openaire +2 more sources