Results 61 to 70 of about 21,779 (217)

A Feasibility Study of the Repurposing of Prazosin to Improve Treatment Outcomes in Men Receiving Radiotherapy for Prostate Cancer (MiniRaP‐00)

The Prostate, Volume 86, Issue 8, Page 891-899, June 2026.
ABSTRACT Background Further work is needed to improve treatment outcomes for prostate cancer (PCa), with the repurposing of the α1‐adrenoreceptor antagonists presenting a potential solution. This feasibility clinical trial presents the first prospective data of the use of an α1‐adrenoreceptor antagonist in men undergoing radiotherapy for PCa.
Liam D. King, David Christie, Daniel Cehic, Wendy Dare, Russ Chess‐Williams, Donna Sellers, Catherine McDermott, Alexandra McCarthy, Shailendra Anoopkumar‐Dukie   +8 more
wiley   +1 more source

Age‐Dependent Differences in Canakinumab Safety: A Comprehensive Pharmacovigilance Analysis Using the FAERS Database

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT While the efficacy of canakinumab, an anti‐interleukin‐1β monoclonal antibody, is well‐established, its safety profile, particularly across different age groups, remains inadequately explored. Using the FDA Adverse Event Reporting System (FAERS) database, this study evaluated postmarketing safety by analyzing adverse event (AE) reports from ...
Youyang Wang, Ngasin Lam, Xiaoming Huang, Yang Jiao   +3 more
wiley   +1 more source

A multicenter, open-label, long-term safety and tolerability study of DFN-02, an intranasal spray of sumatriptan 10 mg plus permeation enhancer DDM, for the acute treatment of episodic migraine. [PDF]

, 2017
BackgroundDFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM).
Allenby, Kent, Brand-Schieber, Elimor, Cady, Roger K, Munjal, Sagar, Rapoport, Alan M, Spierings, Egilius LH   +5 more
core   +1 more source

Acute Systemic Complications Following High‐Dose Semaglutide Reinitiation in an Elderly Patient

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Severe gastrointestinal intolerance with systemic complications can occur within hours of reinitiating high‐dose semaglutide after a prolonged treatment interruption, even in patients who previously tolerated the medication. Elderly patients with comorbidities may be particularly vulnerable.
Jay Mehta, Brent Tai, Johnathan Frunzi
wiley   +1 more source

Diagnosis of acute diverticulitis colon and its purulent – destructive complications

Сучасні медичні технології
Aim. To determine the diagnostic effectiveness of clinical, laboratory and instrumental methods for detecting acute diverticulitis and its perforation complications. Materials and methods.
M. M. Mylytsia, O. B. Tymchuk, V. S. Kazakov   +2 more
doaj   +1 more source

Incidental Detection of Asymptomatic Colonic Anisakiasis During Surveillance Colonoscopy: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Anisakiasis is a parasitic infection caused by ingestion of raw or undercooked seafood containing Anisakis larvae. Although gastric involvement is common, colonic anisakiasis is rare and may be asymptomatic, making diagnosis difficult without endoscopic evaluation.
Masashi Omori, Kenta Shibahara, Takashi Murakami, Eiji Kamba, Kei Nomura, Hirofumi Fukushima, Dai Ishikawa, Mariko Hojo, Tomoyoshi Shibuya, Akihito Nagahara   +9 more
wiley   +1 more source

Avoiding or reversing Hartmann's procedure provides improved quality of life after perforated diverticulitis [PDF]

, 2010
INTRODUCTION: The existing literature regarding acute perforated diverticulitis only reports about short-term outcome; long-term following outcomes have not been assessed before.
Busschbach, J.J. (Jan) van, Gosselink, M.P. (Martijn Pieter), Lange, J.F. (Johan), Vermeulen, J. (Jefrey)   +3 more
core   +1 more source

Bowel Ischemia: A Life‐Threatening Complication of an Infected Urachal Cyst in an Adolescent

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT While infection is a recognized complication of congenital urachal cysts, progression to an inflammatory phlegmon causing bowel ischemia is an exceptionally rare and life‐threatening event in the pediatric population. We report the case of a 14‐year‐old male with a 7‐year history of an infraumbilical mass who presented with an acute abdomen ...
Sheeraz Ali, FNU Saliha, Bilal Ahmad, Abdul Eizad Asif, Khalil El Abdi, Bilal Aslam, Fazeela Bibi, Said Hamid Sadat   +7 more
wiley   +1 more source

Maladaptive Inflammatory Signaling in Old Mice Impairs Colonic Regeneration by Promoting a Sustained Fetal‐Like Epithelial State

Aging Cell, Volume 25, Issue 5, May 2026.
This study explores the impact of aging on regeneration of the mouse colonic epithelium. The authors find that old mice exhibit excessive and prolonged inflammation after infection with Citrobacter, resulting in the maintenance of a fetal regenerative state in epithelial cells, insufficient tissue repair, and death of the animal.
Antonion Korcari, Helen Tauc, Jeff Duggan, Jina Yun, Fabien Wehbe, Spyros Darmanis, Zora Modrusan, Rajita Pappu, David Garfield, Heinrich Jasper, David Castillo‐Azofeifa   +10 more
wiley   +1 more source

ACUTE FLEGMONOUS DIVERTICULITIS OF JEJUNUM AS A CAUSE OF DIFFUSE PURULENT PERITONITIS

Žurnal Grodnenskogo Gosudarstvennogo Medicinskogo Universiteta, 2018
Background. Diverticulum of the small intestine is a pathological saccate protrusion, which communicates directly through the opening with the cavity of the organ.
Dziashuk A. N., Tsylindz I. Т., Avdeeva Е. Y.   +2 more
doaj   +1 more source