Results 201 to 210 of about 194,975 (319)

Unveiling Immune System Perturbations in Early Development Through Zebrafish Models of NADHX Repair Deficiency

Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.
ABSTRACT The vital cofactors NADH and NADPH are prone to hydration, forming hydroxylated redox‐inactive derivatives (NADHX and NADPHX) in cells. These damaged metabolites are repaired by two highly conserved enzymes, an NAD(P)HX dehydratase (NAXD) and an NAD(P)HX epimerase (NAXE).
Myrto Patraskaki, Najmesadat Seyedkatouli, Lisa Schlicker, Marc O. Warmoes, Maria Lorena Cordero‐Maldonado, Ursula Heins‐Marroquin, Carole L. Linster   +6 more
wiley   +1 more source

The characteristics of bacteremia among patients with acute febrile illness requiring hospitalization in Indonesia

, 2022
Pratiwi Soedarmono, Aly Diana, Patricia M. Tauran, Dewi Lokida, Abu Tholib Aman, Bachti Alisjahbana, Dona Arlinda, Emiliana Tjitra, Herman Kosasih, Ketut Tuti Parwati Merati, Mansyur Arif, Muhammad Hussein Gasem, Nugroho Harry Susanto, Nurhayati Lukman, Retna Indah Sugiyono, Usman Hadi, Vivi Lisdawati, Karine G. Fouth Tchos, Aaron Neal, Muhammad Karyana   +19 more
openalex   +1 more source

Metabolic Stroke: Atypical Presentation of Succinic Semialdehyde Dehydrogenase Deficiency

JIMD Reports, Volume 67, Issue 2, March 2026.
ABSTRACT Succinic semialdehyde dehydrogenase (SSADH) deficiency is a rare autosomal recessive neurometabolic disorder caused by biallelic pathogenic variants in ALDH5A1, encoding the mitochondrial enzyme SSADH. This enzyme catalyses the conversion of succinic semialdehyde to succinic acid in the γ‐aminobutyric acid (GABA) degradation pathway.
Sharmila Kiss, Richard J. Leventer, Cormac Duff, Emma Macdonald‐Laurs, Olivia‐Paris Quinn, Fahaz Nazer, Michelle Cao, Abisha Srikumar, Jenzen Dalina, Mary Eggington, Joy Yaplito‐ Lee   +10 more
wiley   +1 more source

Acute Febrile Illness: A Way to Diagnosis

Bangladesh Journal of Medicine
The evaluation of acute febrile illness (AFI) is a crucial aspect of clinical practice, aimed at identifying the underlying cause and guiding appropriate management. AFI refers to a sudden onset of fever without an obvious source, presenting a diagnostic challenge due to the diverse etiologies involved.
openaire   +1 more source

Macrophage Activation Syndrome–Associated Proteins and Enhanced Interferon‐γ Responsiveness in the Plasma Proteome of Patients With Multisystem Inflammatory Syndrome in Children in a Pretreatment Replication Single‐Center Cohort

ACR Open Rheumatology, Volume 8, Issue 2, February 2026.
Objective Multisystem inflammatory syndrome in children (MIS‐C) is a rare hyperinflammatory syndrome that follows SARS‐CoV‐2 infection. Prior plasma proteomic analysis from a 2020 cohort of patients with MIS‐C at our center revealed a profile characterized by thrombotic microangiopathy (TMA), macrophage activation syndrome (MAS)‐associated proteins ...
Sarah McCuaig, Cara Toland, Katharine C. Konvinse, Emily Yang, Paul J. Utz, Laura A. Vella, Audrey R. Odom John, Hamid Bassiri, Edward M. Behrens   +8 more
wiley   +1 more source

Prediction of neutrophil nadir and recovery following paediatric haematopoietic cell transplantation with busulfan conditioning

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 568-578, February 2026.
Aims In haematopoietic cell transplantation (HCT), neutropenia resulting from myelosuppression is an expected endpoint following busulfan‐based conditioning. However, if prolonged, neutropenia can lead to complications like serious infection and death.
Beth Apsel Winger, Joseph W. Polli, Janel Long‐Boyle, Andrew Weber, Jordan Brooks, Jaimit Parikh, Valeriu Damian   +6 more
wiley   +1 more source

Pharmacokinetics of teicoplanin in paediatric patients—A systematic review of current literature

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 396-421, February 2026.
Background and Objective Teicoplanin is commonly used in children to treat gram‐positive infections and is sometimes used off‐label prophylactically in surgical or paediatric oncology settings. The pharmacokinetics (PK) of teicoplanin in children exhibit considerable variability, such as in critically ill children or those with renal impairment.
Noa E. Wijnen, Daan J. Touw, Kim Klein, Gertjan J. L. Kaspers, Paola Mian   +4 more
wiley   +1 more source

Unsuspected Dengue as a Cause of Acute Febrile Illness in Children and Adults in Western Nicaragua

, 2020
Megan E. Reller, Aravinda M. de Silva, Jeremy J. Miles, Ramesh Jadi, Anne Broadwater, Katie Walker, Christopher W. Woods, Orlando Mayorga, Armando Matute   +8 more
openalex   +1 more source

Virtual healthcare compared to hospital care for acute and post‐acute illness in adults: A systematic review and meta‐analysis of randomized controlled trials

British Journal of Clinical Pharmacology, Volume 92, Issue 2, Page 374-395, February 2026.
Aim To evaluate the clinical effectiveness, cost‐effectiveness, quality of life (QoL) and patient/caregiver satisfaction associated with VWs/HaH vs. traditional inpatient care in adults with acute or post‐acute illness. Methods We conducted a systematic review and meta‐analysis of randomized controlled trials (RCTs), following PRISMA 2020 guidelines ...
Rana A. Malhis, Stuart E. Bond, Ahmed A. Sadeq, Rani Shatnawi, Barbara R. Conway, Syed Shahzad Hasan, Mamoon A. Aldeyab   +6 more
wiley   +1 more source

Spectrum of acute kidney injury in patients of tropical acute febrile illness in a tertiary hospital

, 2023
Rohit Paras Badge, V. Suresh Babu, Vinay Rathore   +2 more
openalex   +2 more sources