Results 91 to 100 of about 1,934,386 (311)

Influence of IL-10RA and IL-22 polymorphisms on outcome of hepatitis C virus infection.

, 2007
BACKGROUND: Two receptor chains, IL-10RA and IL-10RB, are known to mediate the functions of interleukin-10 (IL-10), which has been shown to be involved in the progression of persistent hepatitis C virus (HCV) infection. Little information is available on
Thursz, Mark, Hill, Adrian V, Hill, Adrian, Knapp, S, Zhang, Lyna, Thomas, Howard C, Yee, LJ, Thomas, HC, Hennig, Branwen J, Wright, Mark, Yee, Leland J, Hennig, BJ, Frodsham, Angela J, Frodsham, AJ, Zhang, L, Wright, M, Hellier, Simon, Thursz, M, Knapp, Susanne, Hellier, S, Hill, AV   +20 more
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Physicians Infrequently Adhere to Hepatitis Vaccination Guidelines for Chronic Liver Disease [PDF]

, 2013
Background and Goals:Hepatitis A (HAV) and hepatitis B (HBV) vaccination in patients with chronic liver disease is an accepted standard of care. We determined HAV and HBV vaccination rates in a tertiary care referral hepatology clinic and the impact of ...
Dhiraj Yadav, Behari, J, Yadav, D, Sweeney Kaitlyn, Thudi Kavitha, Yadav Dhiraj, Kavitha Thudi, Jaideep Behari, Sweeney, Kaitlyn, Thudi, K, Behari, Jaideep, Thudi, Kavitha, Behari Jaideep, Yadav, Dhiraj, Kaitlyn Sweeney, Sweeney, K   +15 more
core   +2 more sources

Harnessing Large‐Scale Multi‐Omics Data for Risk Prediction and Deep Phenotyping of Valvular Heart Diseases in the General Population

Advanced Science, EarlyView.
Large‐scale UK Biobank analyses identify clinical and proteomic signatures for early prediction of valvular heart disease and its subtypes. Proteins add predictive value for VHD, AVS, and MVR, with outcome‐specific compact panels showing translational potential. Multi‐layer evidence highlights matrix remodeling, protease regulation, immune inflammation,
Zhihao Jiang, Yang Liu, Mingyu Song, Ning Chen, Canqing Yu, Jun Lv, Eric Yuk Fai Wan, Lu Qi, Liming Li, Dianjianyi Sun, Bang Zheng   +10 more
wiley   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Case Report: Drug-induced liver injury mimicking hypereosinophilic syndrome

The Turkish Journal of Gastroenterology, 2019
A 56 year-old male presented with cough starting 3 months ago and jaundice and fatigue for one week. Labs showed ALT: 1994 IU/mL, AST: 1331 IU/mL, ALP: 221 U/L, GGT: 182 U/L, T.Bilirubin: 10.1 mg/dL, D.Bilirubin: 7.4 mg/dL, Prothrombin Time/INR: 31.8 sec/
Suna Yapali, Serap Yucel, Nevin Sariguzel, Murat Saruç, Hakan Umit Unal, Arzu Tiftikci, Eser Kutsal, Oguz Fatih Onder, Gurhan Sisman, Cem Aygun, Ozdal Ersoy, Safak Kiziltas, Bahattin Cicek, Nurdan Tozun   +13 more
doaj   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Acute hepatic porphyrias

Porto Biomedical Journal
Abstract Introduction: Porphyrias are rare genetic disorders caused by heme biosynthesis pathway enzyme mutations, leading to porphyrin precursors build up in various tissues and diverse symptoms. This review centers on acute hepatic porphyrias (AHP).
Inês Marques, Pedro Marcos
openaire   +2 more sources

Surveillance for Acute Viral Hepatitis, United States, 2005 [PDF]

" Problem/Condition: In the United States, acute viral hepatitis most frequently is caused by infection with hepatitis A Virus (HAV), hepatitis B Virus (HBV), or hepatitis C Virus (HCV).

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Stimulation requirement and pathogenetic significance of T cells during chronic viral hepatitis. [PDF]

, 2007
Hepatitis B virus (HBV) and Hepatitis C virus (HCV) are important causes of liver inflammation and fibrosis. More than 500 million people are persistently infected worldwide and consequently are at increased risk of developing chronic liver disease ...
Kennedy, P.
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