Results 91 to 100 of about 3,163,010 (367)

Initial Diagnostic Workup of Acute Leukemia: Guideline From the College of American Pathologists and the American Society of Hematology.

Archives of Pathology & Laboratory Medicine, 2017
CONTEXT - A complete diagnosis of acute leukemia requires knowledge of clinical information combined with morphologic evaluation, immunophenotyping and karyotype analysis, and often, molecular genetic testing.
D. Arber, Michael J. Borowitz, Melissa H. Cessna, J. Etzell, K. Foucar, R. Hasserjian, J. D. Rizzo, K. Theil, Sa A. Wang, Anthony T. Smith, R. Rumble, Nicole E. Thomas, James W. Vardiman   +12 more
semanticscholar   +1 more source

FAM136A depletion induces mitochondrial stress and reduces mitochondrial membrane potential and ATP production

FEBS Open Bio, EarlyView.
FAM136A depletion upregulated ROS production, reduced mitochondrial membrane potential (ΔΨ) and ATP production, and upregulated expression of PCK1, PCK2, HMGCS1, and HMGCS2. The expression of both TOMM22 and TOMM20 was also upregulated. FAM136A depletion reduced HCCS that produce holocytochrome c by combining heme to apocytochrome c, and reduced the ...
Yushi Otsuka, Masato Yano
wiley   +1 more source

P1688: LIVING WITH ACUTE LEUKEMIA: A GLOBAL SURVEY OF PATIENTS AND CARERS EXPERIENCE

HemaSphere, 2023
Samantha Nier, Zack Pemberton-Whiteley, Jan Geissler, Anne-Pierre Pickaert, Sophie Wintrich, Cheryl Petruk, Esther Nathalie Oliva, Tatyana Ionova, Sam Salek   +8 more
doaj   +1 more source

Poor Prognosis Biomolecular Factors Are Highly Frequent in Childhood Acute Leukemias From Oaxaca, Mexico

Technology in Cancer Research & Treatment, 2020
Objective: To investigate the cellular and molecular epidemiology of acute leukemias in vulnerable populations of children and adolescents in Oaxaca de Juarez, Mexico.
Gerardo Juárez-Avendaño MSc, Nuria Citlalli Luna-Silva MD, Euler Chargoy-Vivaldo MD, Laura Alicia Juárez-Martínez MD, Mayra Noemí Martínez-Rangel BS, Noemí Zárate-Ortiz BS, Edith Martínez-Valencia BS, Briceida López-Martínez MD, Rosana Pelayo PhD, Juan Carlos Balandrán PhD   +9 more
doaj   +1 more source

Classification of acute lymphoblastic leukemia using deep learning

Microscopy research and technique (Print), 2018
Acute Leukemia is a life‐threatening disease common both in children and adults that can lead to death if left untreated. Acute Lymphoblastic Leukemia (ALL) spreads out in children's bodies rapidly and takes the life within a few weeks.
A. Rehman, Naveed Abbas, T. Saba, Syed Ijaz Ur Rahman, Zahid Mehmood, H. Kolivand   +5 more
semanticscholar   +1 more source

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Predictive value of minimal residual disease in Philadelphia-chromosome-positive acute lymphoblastic leukemia treated with imatinib in the European intergroup study of post-induction treatment of Philadelphia-chromosome-positive acute lymphoblastic leukemia, based on immunoglobulin/T-cell receptor and BCR/ABL1 methodologies

Haematologica, 2018
The prognostic value of minimal residual disease (MRD) in Philadelphia-chromosome-positive (Ph+) childhood acute lymphoblastic leukemia (ALL) treated with tyrosine kinase inhibitors is not fully established.
Giovanni Cazzaniga, Paola De Lorenzo, Julia Alten, Silja Röttgers, Jeremy Hancock, Vaskar Saha, Anders Castor, Hans O. Madsen, Virginie Gandemer, Hélène Cavé, Veronica Leoni, Rolf Köhler, Giulia M. Ferrari, Kirsten Bleckmann, Rob Pieters, Vincent van der Velden, Jan Stary, Jan Zuna, Gabriele Escherich, Udo zur Stadt, Maurizio Aricò, Valentino Conter, Martin Schrappe, Maria Grazia Valsecchi, Andrea Biondi   +24 more
doaj   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia

Haematologica, 2019
Differentiation therapies achieve remarkable success in acute promyelocytic leukemia, a subtype of acute myeloid leukemia. However, excluding acute promyelocytic leukemia, clinical benefits of differentiation therapies are negligible in acute myeloid ...
Jianbiao Zhou, Jessie Yiying Quah, Yvonne Ng, Jing-Yuan Chooi, Sabrina Hui-Min Toh, Baohong Lin, Tuan Zea Tan, Hiroki Hosoi, Motomi Osato, Qihui Seet, A.G. Lisa Ooi, Bertil Lindmark, Mark McHale, Wee-Joo Chng   +13 more
doaj   +1 more source

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia

Nature Communications, 2018
Mcl-1 is a member of the Bcl-2 family of proteins that promotes cell survival by preventing induction of apoptosis in many cancers. High expression of Mcl-1 causes tumorigenesis and resistance to anticancer therapies highlighting the potential of Mcl-1 ...
A. Tron, M. Belmonte, Ammar Adam, Brian Aquila, Brian Aquila, L. Boise, E. Chiarparin, Justin Cidado, K. Embrey, E. Gangl, F. Gibbons, G. Gregory, G. Gregory, D. Hargreaves, J. A. Hendricks, J. Johannes, R. Johnstone, R. Johnstone, S. Kazmirski, J. Kettle, L. Michelle, Shannon M Matulis, A. Nooka, M. Packer, Bo Peng, P. Rawlins, Daniel W. Robbins, A. Schuller, Nancy Su, Wenzhan Yang, Q. Ye, Xiaolan Zheng, J. Secrist, E. Clark, David M. Wilson, S. Fawell, A. Hird   +36 more
semanticscholar   +1 more source