Results 91 to 100 of about 1,710,059 (263)

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Immunotherapy in Acute Leukemia [PDF]

Seminars in Hematology, 2009
Recent advances in immunotherapy of cancer may represent a successful example in translational research, in which progress in knowledge and technology in immunology has led to new strategies of immunotherapy, and even past failures in many clinical trials have led to a better understanding of basic cancer immunobiology.
openaire   +2 more sources

MicroRNA let-7a-3 gene methylation is associated with karyotyping, CEBPA promoter methylation, and survival in acute myeloid leukemia

, 2017
Let-7a-3 transcribes the miRNA let-7a, of which the expression is dysregulated in cancer. We evaluated the significance of let-7a-3 gene methylation in patients with de novo acute myeloid leukemia (AML).
Ko, Ya-Chen;Fang, Woei-Horng;Lin, Tsung-Chin;Hou, Hsin-An;Chen, Chien-Yuan;Tien, Hwei-Fang;Lin, Liang-In, 林亮音;陳建源;方偉宏;田蕙芬;侯信安   +1 more
core   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Analysis of outcomes following change in granulocyte colony-stimulating factor administration policy in multiple myeloma patients receiving melphalan autologous bone marrow transplant

Transplantation Reports
Background: Engraftment is a determining factor for hospital discharge following autologous hematopoietic stem cell transplant (auto-HSCT). Delays in engraftment can lead to a longer hospital length of stay (LOS), infection, and higher financial costs ...
Maranda Renouard, Julie Asch, Jacob Wilkes, Daanish Hoda, Prashant Sharma, Riki Ashment, Ryan Jensen, Bradley Hunter   +7 more
doaj   +1 more source

Cytoplasmic mutated nucleophosmin is stable in primary leukemic cells and in a xenotransplant model of NPMc+ acute myeloid leukemia in SCID mice

Haematologica, 2008
We investigated the NPM1 mutation status or subcellular expression of NPM protein (nuclear vs. aberrant cytoplasmic) at diagnosis and relapse in 125 patients with acute myeloid leukemia from Italy and Germany.
Brunangelo Falini, Maria Paola Martelli, Cristina Mecucci, Arcangelo Liso, Niccolò Bolli, Barbara Bigerna, Alessandra Pucciarini, Stefano Pileri, Giovanna Meloni, Massimo F. Martelli, Torsten Haferlach, Susanne Schnittger   +11 more
doaj   +1 more source

Prognostic impact of genetic characterization in the GIMEMA LAM99P multicenter study for newly diagnosed acute myeloid leukemia [PDF]

, 2008
Recent advances in genetic characterization of acute myeloid leukemia indicate that combined cytogenetic and molecular analyses provide better definition of prognostic groups.
A. Piciocchi, Amadori, S, M. Vignetti, Cristina Mecucci, Izzo, B, Francesco Lo Coco, S. Amadori, Falini, B, A. Bardi, Bardi, A, Saglio, G, P. G. Pelicci, MANDELLI, Franco, P. Fazi, B. Falini, Antonio Cuneo, Nicoletta Testoni, Simona Iacobelli, Sergio Amadori, Saglio, G., Mancini, M, Iacobelli, S, P.G. Pelicci, Mecucci, C, C. Mecucci, Vignetti, M, Brunangelo Falini, La Starza, R, Daniela Diverio, Marco Mancini, Pier Giuseppe Pelicci, Bolli, N, Fazi, P, Alfonso Piciocchi, M. Mancini, N. Bolli, D. Diverio, Franco Mandelli, N. Testoni, IACOBELLI, SIMONA, Cilloni, D, LO COCO, FRANCESCO, S. Iacobelli, Acute Leukemia Working, R. La Starza, Giuseppe Saglio, Lo-Coco, F, Roberta La Starza, VIGNETTI, Marco, G. Saglio, Cuneo, A, Paola Fazi, Testoni, N, F. Pane, Daniela Cilloni, F. Mandelli, Acute Leukemia Working Party of the GIMEMA group, D. Cilloni, PANE, FABRIZIO, F. Lo Coco, Antonella Bardi, Piciocchi, A, IZZO, BARBARA, Niccolò Bolli, AMADORI, SERGIO, Pelicci, P, Marco Vignetti, Mandelli, F, Diverio, D, B. Izzo, A. Cuneo, G. Saglio For The Acute Leukemia Working Party Of The Gimema Group, Pane, F, Saglio G, Francesco Lo-Coco, CUNEO, Antonio, Vignetti M, Mandelli F, Cilloni D, Testoni N, Fabrizio Pane, Lo Coco F, Bolli N, Izzo B, Barbara Izzo, Piciocchi A, Bardi A, Iacobelli S, La Starza R, Pane F, Falini B, Pelicci PG, Mecucci C, Giuseppe Sagliofor the Acute Leukemia Working Party of the GIMEMA group, Diverio D, Mancini M, Amadori S, Fazi P, Cuneo A, LoCoco F, Lacobelli S   +100 more
core   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Rationale for an international consortium to study inherited genetic susceptibility to childhood acute lymphoblastic leukemia

Haematologica, 2011
Acute lymphoblastic leukemia is the major pediatric cancer in developed countries. To date most association studies of acute lymphoblastic leukemia have been based on the candidate gene approach and have evaluated a restricted number of polymorphisms ...
Amy L. Sherborne, Kari Hemminki, Rajiv Kumar, Claus R. Bartram, Martin Stanulla, Martin Schrappe, Eleni Petridou, Ágnes F. Semsei, Csaba Szalai, Daniel Sinnett, Maja Krajinovic, Jasmine Healy, Marina Lanciotti, Carlo Dufour, Stefania Indaco, Eman A El-Ghouroury, Ruchchadol Sawangpanich, Suradej Hongeng, Samart Pakakasama, Anna Gonzalez-Neira, Evelia L. Ugarte, Valeria P. Leal, Juan P.M. Espinoza, Azza M. Kamel, Gamal T.A. Ebid, Eman R. Radwan, Serap Yalin, Erdinc Yalin, Mehmet Berkoz, Jill Simpson, Eve Roman, Tracy Lightfoot, Fay J. Hosking, Jayaram Vijayakrishnan, Mel Greaves, Richard S. Houlston   +35 more
doaj   +1 more source