Results 91 to 100 of about 1,893,034 (314)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Genetic modification and effector functions of natural killer cells in acute myeloid leukemia [PDF]

, 2006
Acute myeloid leukemia (AML) is characterized by a poor long-term outcome in the majority of patients following conventional treatment with chemotherapy.
Siegler, Uwe
core   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Analysis of outcomes following change in granulocyte colony-stimulating factor administration policy in multiple myeloma patients receiving melphalan autologous bone marrow transplant

Transplantation Reports
Background: Engraftment is a determining factor for hospital discharge following autologous hematopoietic stem cell transplant (auto-HSCT). Delays in engraftment can lead to a longer hospital length of stay (LOS), infection, and higher financial costs ...
Maranda Renouard, Julie Asch, Jacob Wilkes, Daanish Hoda, Prashant Sharma, Riki Ashment, Ryan Jensen, Bradley Hunter   +7 more
doaj   +1 more source

The PML-RAR alpha transcript in long-term follow-up of acute promyelocytic leukemia patients [PDF]

, 2001
Background and Objectives. Detection of PML-RAR alpha transcripts by RT-PCR is now established as a rapid and sensitive method for diagnosis of acute promyelocytic leukemia (APL), Although the majority of patients in longterm clinical remission are ...
Gameiro, P, Diamond, J, Foroni, L, Silva, AL, Mehta, AB, Prentice, HG, Carrara, P, Vieira, S, Guimaraes, JE, Parreira, A, Hoffbrand, AV, de Sousa, AB   +11 more
core  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Cytoplasmic mutated nucleophosmin is stable in primary leukemic cells and in a xenotransplant model of NPMc+ acute myeloid leukemia in SCID mice

Haematologica, 2008
We investigated the NPM1 mutation status or subcellular expression of NPM protein (nuclear vs. aberrant cytoplasmic) at diagnosis and relapse in 125 patients with acute myeloid leukemia from Italy and Germany.
Brunangelo Falini, Maria Paola Martelli, Cristina Mecucci, Arcangelo Liso, Niccolò Bolli, Barbara Bigerna, Alessandra Pucciarini, Stefano Pileri, Giovanna Meloni, Massimo F. Martelli, Torsten Haferlach, Susanne Schnittger   +11 more
doaj   +1 more source

To the study of acute leukemia

Kazan medical journal, 1903
Virshow first noticed, as we have seen, the creature of "white blood", defended, thanks to his observation and tireless energy, the independence of this disease, made the difference between him, pieemia and leukocytosis, gave him the name "leukemia" and outlined in some detail both pathological anatomy and clinical features.
openaire   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Rationale for an international consortium to study inherited genetic susceptibility to childhood acute lymphoblastic leukemia

Haematologica, 2011
Acute lymphoblastic leukemia is the major pediatric cancer in developed countries. To date most association studies of acute lymphoblastic leukemia have been based on the candidate gene approach and have evaluated a restricted number of polymorphisms ...
Amy L. Sherborne, Kari Hemminki, Rajiv Kumar, Claus R. Bartram, Martin Stanulla, Martin Schrappe, Eleni Petridou, Ágnes F. Semsei, Csaba Szalai, Daniel Sinnett, Maja Krajinovic, Jasmine Healy, Marina Lanciotti, Carlo Dufour, Stefania Indaco, Eman A El-Ghouroury, Ruchchadol Sawangpanich, Suradej Hongeng, Samart Pakakasama, Anna Gonzalez-Neira, Evelia L. Ugarte, Valeria P. Leal, Juan P.M. Espinoza, Azza M. Kamel, Gamal T.A. Ebid, Eman R. Radwan, Serap Yalin, Erdinc Yalin, Mehmet Berkoz, Jill Simpson, Eve Roman, Tracy Lightfoot, Fay J. Hosking, Jayaram Vijayakrishnan, Mel Greaves, Richard S. Houlston   +35 more
doaj   +1 more source