Results 131 to 140 of about 420,896 (315)

Reentry of nondividing leukemic cells into a proliferative phase in acute childhood leukemia [PDF]

, 1969
E. Fred Saunders, Alvin M. Mauer
openalex   +1 more source

Microglial Deletion of Hrh4 Alleviates Alzheimer's Disease Pathologies by Enhancing Microglial Phagocytosis of Amyloid‐β and Tau

Advanced Science, EarlyView.
Histamine H4 receptor (H4R) antagonist VUF6002 mimics low‐dose X‐ray irradiation in aged Alzheimer's disease (AD) mice, enhancing microglial clearance of amyloid‐beta/hyperphosphorylated tau aggregates and restoring cognition. Microglial H4R deletion activates cAMP/TGF‐β1/Smad3 pathway, enhancing phagocytosis, while TGF‐β receptor 1 deletion abolishes ...
Yi‐Jun Xu, Tan Wu, Larry Tso‐Lun Lo, Chi‐Chiu Ko, Xin Wang, Chi Him Eddie Ma   +5 more
wiley   +1 more source

The Effectiveness of Combinations of Antileukemic Agents in Inducing and Maintaining Remission in Children with Acute Leukemia

, 1965
Emil Frei, Myron Karon, Robert H. Levin, Emil J. Freireich, Robert Taylor, Juliet Hananian, Oleg S. Selawry, James F. Holland, Barth Hoogstraten, Irving J. Wolman, Esshagh Abir, A Sawitsky, Stanley Chun-Wei Lee, S Mills, E. Omer Burgert, Charles L. Spurr, RICHARD B. PATTERSON, Franklin G. Ebaugh, G. Watson James, John H. Moon   +19 more
openalex   +1 more source

Studies of Sequential and Combination Antimetabolite Therapy in Acute Leukemia: 6-Mercaptopurine and Methotrexate [PDF]

, 1961
Emil Frei, Emil J. Freireich, Edmund A. Gehan, Donald Pinkel, James F. Holland, Oleg S. Selawry, Farid I. Haurani, Charles L. Spurr, Donald M. Hayes, G. Watson James, Harvey Rothberg, D. Bruce Sodee, R. Wayne Rundles, LESLIE R. SCHROEDER, Barth Hoogstraten, Irving J. Wolman, Demetrius Traggis, Talbert Cooper, Benjamin R. Gendel, Franklin G. Ebaugh, Robert Taylor   +20 more
openalex   +1 more source

Stimuli‐Responsive CuFeTe2 Nanosheets for Amplified Cuproptosis/Ferroptosis in Triple‐Negative Breast Cancer Therapy

Advanced Science, EarlyView.
Dual‐stimuli‐responsive CuFeTe2 nanosheets (CFT) induce cuproptosis/ferroptosis via TME‐responsive Fe2⁺/Cu2⁺ release and NIR‐II photothermal effects, amplifying ROS and depleting HSP70/ATP to trigger ICD and immune activation, while ensuring biocompatible renal clearance for TNBC therapy.
Molin Liu, Jian Zheng, Mengqi Yu, Qirui Wang, Yi Yuan, Nannan Shao, Xiaoliang Yang, Tianxi Shen, Li Wang, Aiyun Li, Rui Liu, Jimin Cao, Xi Liu, Fangfang Cao, Yanlin Feng   +14 more
wiley   +1 more source

Treatment of adult acute leukemia with arabinosylcytosine and thioguanine [PDF]

, 1969
Toby Gee, Kou-Ping Yu, Bayard D. Clarkson   +2 more
openalex   +1 more source

Variations in Innate Immune Cell Subtypes Correlate with Epigenetic Clocks, Inflammaging and Health Outcomes

Advanced Science, EarlyView.
This study uses a high‐resolution DNA methylation reference panel for 19 immune cell‐types, as well as transcriptomic, metabolomic, and large population cohort data to show that age‐related epigenetic heterogeneity within monocytes correlates with inflammaging, biological age, and all‐causemortality, and does so more strongly than existing monocyte ...
Xiaolong Guo, Josephine A. Robertson, Andrea Aparicio, Kirsten Seale, Qingwen Chen, Anne Richmond, Zhaozhen Du, Mahnoor Sulaiman, Shijie C Zheng, Esteban Ballestar, Charlotte AM Cecil, Bastiaan T Heijmans, Steve Horvath, Varun B. Dwaraka, Jessica Lasky‐Su, Ryan Smith, Riccardo E. Marioni, Andrew E Teschendorff   +17 more
wiley   +1 more source

Alkaline Phosphatase Activity of Exudative Leukocytes in Acute Leukemia [PDF]

, 1961
Pasquale E. Perillie, Stuart C. Finch
openalex   +1 more source

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

Proliferation Kinetics of Acute Leukemia Cells in Relation to the Chemotherapy [PDF]

, 1967
F Gavosto, Alessandro Pileri, Luigi Pegoraro   +2 more
openalex   +1 more source