Results 191 to 200 of about 361,404 (250)

Plasma lipidomic and fungal signatures predict early mortality in acute liver failure. [PDF]

Clin Mol Hepatol
Kim YJ, Kim JW.
europepmc   +1 more source

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

Acute Liver Failure: Is Acetaminophen the Only Culprit? [PDF]

Cureus
McLaughlin SD, Amaral JZ, Thomas J, Amaral KZ, Scalzo A.   +4 more
europepmc   +1 more source

Microfluidic Modeling of Macrophage‐Induced Cardiac Inflammation Using NF‐κB Reporter Cardiomyocytes

Advanced Healthcare Materials, EarlyView.
A cardiac inflammation model was developed to enable real‐time analysis of macrophage‐cardiomyocyte interactions using NF‐κB‐reporter cardiomyocytes and a microfluidic co‐culture system. A MATLAB‐based model was implemented to optimize cell density and medium resupply based on TNFα diffusion kinetics. Activation thresholds and stress responses in NF‐κB‐
Chao Liu, Xi Rui Qiang Lu, Seoyoung Jeong, Douglas H. Wu, Rodrigo A. Somoza, Parameswaran Ramakrishnan, Samuel E. Senyo   +6 more
wiley   +1 more source

The endothelial growth factor angiopoietin-2 is an accurate prognostic biomarker in patients with acetaminophen-induced acute liver failure. [PDF]

Toxicol Sci
Umbaugh DS, Nguyen NT, Curry SC, Rule JA, Lee WM, Ramachandran A, Jaeschke H, Acute Liver Failure Study Group .   +7 more
europepmc   +1 more source

Spherical Skin Model: Stratified Co‐Culture of Fibroblasts and Keratinocytes on Spherical Beads Toward Compound Screening

Advanced Healthcare Materials, EarlyView.
Models of the human skin must combine the relevant biological contents and suitable biomaterials with the correct spatial organization. Performing compound screening on such in vitro models also requires fast and reproducible production methods of the models.
Elisa Lenzi, Nadia Vertti‐Quintero, Julien Husson, Anne‐Laure Bulteau, Carine Nizard, Karl Pays, Sébastien Sart, Charles N. Baroud   +7 more
wiley   +1 more source

Therapeutic plasma exchange in amatoxin associated acute liver failure-results from the multi-center Amanita-PEX study. [PDF]

Crit Care
Stahl K, Nalbant B, Pape T, Breteau I, Coirier V, Cardoso FS, de Haan J, Janik MK, Wasmuth JC, Madaleno J, Merle U, Frohme J, Tepasse PR, Müller M, Große K, Linke A, Mareljic N, Larsen FS, Dahlqvist G, Kolev M, Schulze M, Willuweit K, Janke-Maier P, Dondorf F, Fierro-Angulo ÓM, Geerts A, Toapanta D, Dejean C, Alharthi M, Reverter E, Schenk H, Raevens S, Macías-Rodríguez RU, Rauchfuß F, Berg CP, Schmidt H, Geier A, Semmo N, Lanthier N, Bjerring PN, Lange CM, Sterneck M, Bruns T, Schmid S, van de Loo D, Demir M, Boettler T, Borges C, Nattermann J, Wronka K, den Hoed CM, Marques HP, Artru F, Levesque E, Wedemeyer H, Campos-Murguia A, Taubert R, Amanita-PEX-study group.   +57 more
europepmc   +1 more source

Preliminary Study of a Ninj1‐Loaded Bimodal Ultrasound/NIR Fluorescence Targeted Molecular Probe for Diagnosing Early‐Stage Inflammation in Coronary Microvascular Dysfunction

Advanced Healthcare Materials, EarlyView.
Coronary microvascular dysfunction (CMD) targeting remains a challenge for precise diagnosis. This work presents a dual‐modal nanoprobe (T‐IR780‐NBs) that combines ultrasound contrast with near‐infrared fluorescence. This technology utilizes proteomics‐derived antibodies that specifically localize to inflamed and injured cardiac tissue, enabling ...
Xiaohui Xu, Lina Guan, Baihetiya Tayier, Chen Yuan, Shangke Chen, Qi Shi, Yuming Mu   +6 more
wiley   +1 more source

Paediatric acute liver failure: A prospective, nationwide, population-based surveillance study in Germany. [PDF]

J Pediatr Gastroenterol Nutr
Lenz D, Abdulaziz M, Peters B, Wagner M, Schlieben LD, Corman VM, Baumann U, Bufler P, Dattner T, Ganschow R, Genzel K, Hammann N, Hartleif S, Hegen B, Henning S, Hoerning A, Jankofsky M, Junge N, Kathemann S, Knoppke B, Kohl-Sobania M, Laass M, Lainka E, Lurz E, Melter M, Müller H, Pilic D, Ries M, Schiefele L, Schwerd T, Sturm E, Wegner M, Urschitz MS, Garbade SF, Wenning D, Drosten C, Fichtner A, Kölker S, Hoffmann GF, Prokisch H, Staufner C.   +40 more
europepmc   +1 more source

The Floor‐Ceiling‐Chip, or 2 × 2D = Pseudo‐3D—Approaching 3D Cell Morphology and Organization between Two Opposing 2D Substrates with Cell‐Adhesive Protein Micropatterns

Advanced Healthcare Materials, EarlyView.
Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...
Urandelger Tuvshindorj, Francesca Giacomini, Esra Güben Kaçmaz, Tim ten Brink, Lorenzo Moroni, Zeinab Tahmasebi Birgani, Clemens van Blitterswijk, Pamela Habibović, Stefan Giselbrecht, Jan de Boer, Roman Truckenmüller   +10 more
wiley   +1 more source