Results 91 to 100 of about 401,465 (309)

Simulation-Based Hypothesis Testing of High Dimensional Means Under Covariance Heterogeneity [PDF]

Biometrics 2017, Vol. 73, No. 4, 1300-1310, 2014
In this paper, we study the problem of testing the mean vectors of high dimensional data in both one-sample and two-sample cases. The proposed testing procedures employ maximum-type statistics and the parametric bootstrap techniques to compute the critical values.
arxiv   +1 more source

Inotuzumab ozogamicin in pediatric patients with relapsed/refractory acute lymphoblastic leukemia

Leukemia, 2018
Although inotuzumab ozogamicin (InO) is recognized as an effective agent in relapsed acute lymphoblastic leukemia (ALL) in adults, data on safety and efficacy in pediatric patients are scarce.
D. Bhojwani, R. Sposto, N. Shah, V. Rodriguez, C. Yuan, M. Stetler-Stevenson, M. O’Brien, Jennifer L. McNeer, Amrana Quereshi, A. Cabannes, P. Schlegel, C. Rossig, L. Dalla-Pozza, K. August, S. Alexander, J. Bourquin, M. Zwaan, E. Raetz, M. Loh, S. Rheingold   +19 more
semanticscholar   +1 more source

A dyad of lymphoblastic lysosomal cysteine proteases degrades the antileukemic drug L-asparaginase [PDF]

, 2009
l-Asparaginase is a key therapeutic agent for treatment of childhood acute lymphoblastic leukemia (ALL). There is wide individual variation in pharmacokinetics, and little is known about its metabolism.
Abshire, Asselin, Aung, Carly Leighton, Catherine X. Moss, Clare Dempsey, Colin Watts, Fine, Frederik W. van Delft, Hany Ariffin, JiZhong Liu, Marc N. Offman, Marcin Krol, Mark Holland, Monika Essink, Naina Patel, Offman, Paul A. Bates, Rizzari, Seema Alexander, Shekhar Krishnan, Tim O.B. Eden, van Zelm, Vaskar Saha   +23 more
core   +4 more sources

Acute lymphoblastic leukemia of childhood presenting as aplastic anemia: report of two cases

Revista Brasileira de Hematologia e Hemoterapia, 2012
Acute lymphoblastic leukemia is the most common malignancy in pediatric patients; its diagnosis is usually easy to establish as malignant lymphoblasts invade the bone marrow and peripheral blood.
Laura Villarreal-Martínez, José Carlos Jaime-Pérez, Marisol Rodríguez-Martínez, Oscar González-Llano, David Gómez-Almaguer   +4 more
doaj   +1 more source

Langerhans cell histiocytosis developing acute lymphoblastic leukemia

SAGE Open Medical Case Reports, 2022
The sequential occurrence of Langerhans cell histiocytosis and acute leukemia in only one individual has been reported previously; however, it is rarely observed that Langerhans cell histiocytosis can transform into acute lymphoblastic leukemia, and the ...
JinFang Zhang, Sa Zong, Bing Liao
doaj   +1 more source

Acute lymphoblastic leukemia may develop as a result of rapid transformation of a lymphoblast triggered by repeated bone-remodeling during bone-growth [PDF]

arXiv, 2018
Acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL) are two major forms of leukemia that arise from lymphoid cells (LCs). ALL occurs mostly in children and CLL occurs mainly in old people. However, the Philadelphia-chromosome-positive ALL (Ph+-ALL) and the Ph-like ALL occur in both children and adults.
arxiv  

Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia.

Blood, 2019
To study the mechanisms of relapse in acute lymphoblastic leukemia (ALL), we performed whole-genome sequencing of 103 diagnosis-relapse-germline trios and ultra-deep sequencing of 208 serial samples in 16 patients.
Ben-shang Li, Samuel W. Brady, Xiaotu Ma, S. Shen, Yingchi Zhang, Yongjin Li, K. Szlachta, Li Dong, Yu Liu, Fan Yang, Ningling Wang, Diane A. Flasch, Matthew A. Myers, H. Mulder, Lixia Ding, Yanling Liu, Liqing Tian, Kohei Hagiwara, Ke Xu, Xin Zhou, Edgar Sioson, Tianyi Wang, Liu Yang, Jie Zhao, Hui Zhang, Ying Shao, Hongye Sun, Lele Sun, J. Cai, Huiying Sun, Ting-Nien Lin, L. Du, Hui Li, Michael C. Rusch, Michael N. Edmonson, J. Easton, Xiaofan Zhu, Jingliao Zhang, Cheng Cheng, Benjamin J. Raphael, Jingyan Tang, J. Downing, L. Alexandrov, Bingqian Zhou, C. Pui, Jun J. Yang, Jinghui Zhang   +46 more
semanticscholar   +1 more source

Blinatumomab in pediatric patients with relapsed/refractory B‐cell precursor acute lymphoblastic leukemia

European Journal of Haematology, 2020
Pediatric patients with relapsed or refractory acute lymphoblastic leukemia have a poor prognosis. We here assess the response rates, adverse events, and long‐term follow‐up of pediatric patients with relapsed/refractory acute lymphoblastic leukemia ...
M. Queudeville, P. Schlegel, Amadeus T Heinz, T. Lenz, M. Döring, U. Holzer, U. Hartmann, H. Kreyenberg, A. von Stackelberg, M. Schrappe, G. Zugmaier, T. Feuchtinger, P. Lang, R. Handgretinger, M. Ebinger   +14 more
semanticscholar   +1 more source

Genetic variants in ARID5B and CEBPE are childhood ALL susceptibility loci in Hispanics. [PDF]

, 2013
Recent genome-wide studies conducted in European Whites have identified novel susceptibility genes for childhood acute lymphoblastic leukemia (ALL).
Barcellos, Lisa F, Buffler, Patricia A, Chokkalingam, Anand P, Hansen, Helen M, Hsu, Ling-I, Metayer, Catherine, Month, Stacy R, Wiemels, Joseph L   +7 more
core   +3 more sources

Letter regarding Zhao et al. entitled “ gene polymorphisms are associated with risk and chemotherapy prognosis in pediatric patients with acute lymphoblastic leukemia”

Tumor Biology, 2017
Zhao et al. investigated the association between germline genetic polymorphisms in DPYD , the gene encoding dihydropyrimidine dehydrogenase, and (1) the risk of developing pediatric acute lymphoblastic leukemia and (2) outcome of acute lymphoblastic ...
Maarten J Deenen, Linda M Henricks, Gabe S Sonke, Jan HM Schellens, Didier Meulendijks   +4 more
doaj   +1 more source