Results 91 to 100 of about 220,963 (356)

IKAROS and CK2 regulate expression of BCL-XL and chemosensitivity in high-risk B-cell acute lymphoblastic leukemia [PDF]

, 2020
Chunhua Song, Zheng Ge, Yali Ding, Bi‐Hua Tan, Dhimant Desai, Krishne Gowda, Shantu Amin, Raghavendra Gowda, Gavin P. Robertson, Feng Yue, Suming Huang, Vladimir S. Spiegelman, Jonathon L. Payne, Mark E. Reeves, Zafer Gürel, Soumya Iyer, Pavan Kumar Dhanyamraju, Meixian Xiang, Yuka Imamura Kawasawa, Nathália Moreno Cury, José Andrés Yunes, Mary McGrath, Joseph Schramm, Ruijun Su, Yiping Yang, Zhijun Zhao, Xiaoguang Lyu, Markus Müschen, Kimberly J. Payne, Chandrika Gowda, Sinisa Dovat   +30 more
openalex   +1 more source

Super Enhancer Regulatory Gene FYB1 Promotes the Progression of T Cell Acute Lymphoblastic Leukemia by Activating IGLL1 [PDF]

, 2023
Kunlong Zhang, Jun Lu, Fang Fang, Yongping Zhang, Juanjuan Yu, Yanfang Tao, Wenyuan liu, Lihui Lu, Zi-Mu Zhang, Xinran Chu, Jianwei Wang, Xiaolu Li, Yuanyuan Tian, Zhiheng Li, Qian Li, Xu Sang, Li Ma, Ningling Wang, Jian Pan, Shaoyan Hu   +19 more
openalex   +1 more source

New Insights Into Factors Shaping CMV‐Specific T‐Cell Polyfunctionality After Hematopoietic Cell Transplantation

American Journal of Hematology, EarlyView.
ABSTRACT Polyfunctional cytomegalovirus (CMV)‐specific T cells are critical for antiviral immunity in allogeneic hematopoietic cell transplantation (HCT) recipients. However, gaps remain in managing refractory CMV and optimizing virus‐specific cellular therapy (VST).
Alicja Sadowska‐Klasa, Fang Yun Lim, Hu Xie, Danniel Zamora, Terry Stevens‐Ayers, Wendy M. Leisenring, Bradley C. Edmison, Stephen C. De Rosa, Marco Mielcarek, Michael Boeckh   +9 more
wiley   +1 more source

The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia

Haematologica, 2014
Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring ...
Kaat Durinck, Annelynn Wallaert, Inge Van de Walle, Wouter Van Loocke, Pieter-Jan Volders, Suzanne Vanhauwaert, Ellen Geerdens, Yves Benoit, Nadine Van Roy, Bruce Poppe, Jean Soulier, Jan Cools, Pieter Mestdagh, Jo Vandesompele, Pieter Rondou, Pieter Van Vlierberghe, Tom Taghon, Frank Speleman   +17 more
doaj   +1 more source

T-ALL and thymocytes : a message of noncoding RNAs [PDF]

, 2017
In the last decade, the role for noncoding RNAs in disease was clearly established, starting with microRNAs and later expanded towards long noncoding RNAs.
Durinck, Kaat, Speleman, Franki, Taghon, Tom, Van Vlierberghe, Pieter, Wallaert, Annelynn   +4 more
core   +3 more sources

Pharmacogenomics in clinical practice: Biomarker information in Brazilian drug labels

British Journal of Clinical Pharmacology, EarlyView.
This review examines the PGx annotations in package inserts (bulas in Brazilian Portuguese) approved by ANVISA, the Brazilian Health Regulatory Agency, for 19 gene–drug pairs with strong or moderate recommendations for initial dosing alteration in the CPIC (Clinical Pharmacogenetic Implementation Consortion) guidelines and PGx testing required or ...
Guilherme Suarez‐Kurtz
wiley   +1 more source

Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia

Haematologica, 2011
Background Mutations in the PHF6 gene were recently described in patients with T-cell acute lymphoblastic leukemia and in those with acute myeloid leukemia.
Qian Wang, Huiying Qiu, Hui Jiang, Lili Wu, Shasha Dong, Jinlan Pan, Wenjuan Wang, Nana Ping, Jing Xia, Aining Sun, Depei Wu, Yongquan Xue, Hans G. Drexler, Roderick A. F. MacLeod, Suning Chen   +14 more
doaj   +1 more source

Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies. [PDF]

, 2018
Human cells express thousands of different surface proteins that can be used for cell classification, or to distinguish healthy and disease conditions.
Adams, Jarrett J, Geng, Huimin, Hornsby, Michael, Hu, Amy, Julien, Olivier, Martinko, Alexander J, Moffat, Jason, Mou, Yun, Müschen, Markus, Ploder, Lynda, Pollock, Samuel B, Sidhu, Sachdev S, Wells, James A   +12 more
core   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Oncologic Emergencies: Immune-Based Cancer Therapies and Complications [PDF]

, 2020
Cancer therapies have undergone several recent advancements. Current cancer treatments include immune-based therapies comprised of checkpoint inhibitors, and adoptive immunotherapy; each treatment has the potential for complications that differ from ...
Brém, Elizabeth, Koyfman, Alex, Long, Brit Jeffrey   +2 more
core