Results 101 to 110 of about 6,391 (198)

Childhood Cancer Survivors in Latin America: Insights Into Health Outcomes and Information Needs

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Childhood cancer survivors (CCSs) face long‐term health challenges, yet the health and specific needs of Latin American survivors remain underexplored. This study aimed to describe the health‐related, psychosocial late effects, and information needs among CCSs in the region. Methods This mixed‐method study combined quantitative data
Ana Carolina Izurieta‐Pacheco, David H. Noyd, Julia Challinor, Nuria Rossell, Maria Fernanda Olarte‐Sierra, Daniel Bastardo Blanco, Marcela Zubieta, Nicholas B. George, Sara Perez‐Jaume, Anna Felip‐Badia, Viviana Trigoso, Patricia Loggetto, Valeska Gonzalez, Carlos Frias, Sinders Rincon, Roberta Ortiz, Soad Fuentes‐Alabi de Aparicio, Liliana Vásquez Ponce   +17 more
wiley   +1 more source

Reducing General Anesthesia for Lumbar Punctures in Pediatric Patients With Leukemia and Lymphoma, a Quality Improvement Project

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Curative therapy for most children with leukemia and lymphoma includes multiple lumbar punctures (LPs) for the administration of intrathecal chemotherapy, commonly facilitated with deep sedation or general anesthesia (GA). There is ongoing concern about the potential for neurocognitive deficits induced by GA in the developing brain ...
Karen Arane, Daphne Li, Tara Baxter, Bina Gandhi, Karyn Positano, Melissa Howlett, Tobias Everett, Sarah Alexander   +7 more
wiley   +1 more source

Blinatumomab in acute lymphoblastic leukemia [PDF]

Expert Review of Anticancer Therapy, 2016
Caroline Lejeune, Xavier Thomas
openaire   +4 more sources

Sarcopenia in Children and Adolescents With Cancer: A Systematic Review of Diagnostic Assessment Methods

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Sarcopenia, characterized by loss of muscle mass, strength decline, and impaired function, can affect patients with pediatric cancer. This systematic review aimed to identify diagnostic methods for sarcopenia and the associated clinical outcomes in this patient group.
Cláudia Georgiadis Lewandowski, Tais Thomsen Silveira, Yara M. F. Moreno, Heitor P. Leite   +3 more
wiley   +1 more source

Raising Awareness: Real World Data On Palliative Care for Advanced Pediatric Cancers in Bavaria

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Early integration of palliative care in children with cancer provides a variety of positive effects and is recommended at diagnosis. However, barriers often delay its implementation, and palliative care remains underutilized. This study provides real‐world data on palliative care and integration in pediatric oncology in a high ...
Nadja Nehls, Maja Börner, Sebastian Ziegelmayer, Bernhard Haller, Felicitas Ferrari‐von Klot, Markus Metzler, Michael C. Frühwald, Paul‐Gerhardt Schlegel, Selim Corbacioglu, Tobias Feuchtinger, Irene Teichert‐von Lüttichau   +10 more
wiley   +1 more source

Push Forward Clinical Management of Hematological Toxicity due to Lenalidomide Overexposure: Model‐Informed Precision Dosing for Chinese Population With Renal Insufficiency

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Dose‐dependent hematological toxicity of lenalidomide has been reported previously, and thus, there is a clinical need for dose individualization to manage toxicities. The objectives of this study were to explore optimal individualized dosing regimens for Chinese B‐cell malignancies patients with varying degrees of renal function, and to push ...
Yi Ma, Zaiwei Song, Hao Bing, Huan He, Libo Zhao, Rongsheng Zhao   +5 more
wiley   +1 more source

Nanoparticle Therapeutics in Clinical Perspective: Classification, Marketed Products, and Regulatory Landscape

Small, EarlyView.
This review presents a detailed overview of clinically approved nanoparticle therapeutics, classifying them by type and discussing their unique advantages in drug delivery. It highlights regulatory challenges across global markets and emphasizes the need for adaptive approval pathways.
Nimeet Desai, Dhwani Rana, Mitali Patel, Neha Bajwa, Rajendra Prasad, Lalitkumar K. Vora   +5 more
wiley   +1 more source

CRISPR/Cas9‐edited tumor‐associated immune cells in cancer immunotherapy

VIEW, EarlyView.
Abstract Immuno‐oncology represents an emerging field that has significantly transformed tumor therapeutics, with immune cells serving as the cellular foundations of cancer immunotherapy. Due to its high efficiency and sensitivity, CRISPR/Cas9 genome editing is a highly promising technique for precise and rapid gene modification.
Yuhui Ma, Junxin Chen, Yuan Du, Zhihao Cao, Weizhi Ji, Yuyu Niu, Zebin Yang   +6 more
wiley   +1 more source

Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia

Journal of Medical Imaging and Radiation Oncology, EarlyView.
ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes, Rishi S. Kotecha, Derek J. Roebuck   +2 more
wiley   +1 more source

Opportunities and Challenges of Population Pharmacogenomics

Annals of Human Genetics, EarlyView.
ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou, Yoomi Park, Mahamadou D. Camara, Volker M. Lauschke   +3 more
wiley   +1 more source