Results 71 to 80 of about 401,465 (309)

Pediatric acute lymphoblastic leukemia treatment protocols improvement: emphasis on minimal residual disease

Онкогематология, 2020
Treatment of acute lymphoblastic leukemia (ALL) in children during the last 50 years has changed significantly, which has increased the survival of patients from 10–15 % in the early 60s to 80–85 % by the mid-2000s.
M. A. Shervashidze, T. T. Valiev
doaj   +1 more source

Mathematical Modeling of Leukemia Chemotherapy in Bone Marrow [PDF]

arXiv, 2022
Acute Lymphoblastic Leukemia (ALL) accounts for the 80% of leukemias when coming down to pediatric ages. Survival of these patients has increased by a considerable amount in recent years. However, around 15-20% of treatments are unsuccessful. For this reason, it is definitely required to come up with new strategies to study and select which patients ...
arxiv  

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

New England Journal of Medicine, 2014
BACKGROUND Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome.
K. Roberts, Yongjin Li, D. Payne-Turner, R. Harvey, Yung‐Li Yang, Deqing Pei, K. McCastlain, L. Ding, Charles Lu, Guangchun Song, Jing Ma, J. Becksfort, Michael C. Rusch, Shann-Ching Chen, J. Easton, Jinjun Cheng, Kristy Boggs, Natalia Santiago-Morales, I. Iacobucci, R. Fulton, Ji-Rong Wen, M. Valentine, Cheng Cheng, S. Paugh, M. Devidas, I. Chen, S. Reshmi, Amy A. Smith, Erin K. Hedlund, P. Gupta, Panduka Nagahawatte, Gang Wu, Xiang Chen, D. Yergeau, Bhavin Vadodaria, H. Mulder, N. Winick, E. Larsen, W. Carroll, N. Heerema, A. Carroll, G. Grayson, S. Tasian, A. Moore, F. Keller, Melissa J. Frei-Jones, J. Whitlock, E. Raetz, D. White, T. Hughes, Jaime M Guidry Auvil, Malcolm A. Smith, G. Marcucci, C. Bloomfield, K. Mrózek, J. Kohlschmidt, W. Stock, S. Kornblau, M. Konopleva, E. Paietta, C. Pui, S. Jeha, M. Relling, W. Evans, D. Gerhard, J. Gastier-Foster, E. Mardis, R. Wilson, M. Loh, J. Downing, S. Hunger, C. Willman, Jinghui Zhang, C. Mullighan   +73 more
semanticscholar   +1 more source

Parthenolide eliminates leukemia-initiating cell populations and improves survival in xenografts of childhood acute lymphoblastic leukemia [PDF]

, 2013
Key Points First report demonstrating in vivo elimination of multiple LIC populations from childhood ALL cases using animal models. In vivo models of leukemia are essential for drug evaluation studies.
Blair, Allison, Cox, Charlotte V, Diamanti, Paraskevi, Moppett, John P   +3 more
core   +1 more source

MicroRNA characterize genetic diversity and drug resistance in pediatric acute lymphoblastic leukemia

Haematologica, 2011
Background MicroRNA regulate the activity of protein-coding genes including those involved in hematopoietic cancers. The aim of the current study was to explore which microRNA are unique for seven different subtypes of pediatric acute lymphoblastic ...
Diana Schotte, Renée X. De Menezes, Farhad Akbari Moqadam, Leila Mohammadi Khankahdani, Ellen Lange-Turenhout, Caifu Chen, Rob Pieters, Monique L. Den Boer   +7 more
doaj   +1 more source

Semisynthetic aurones A14 protects against T-cell acute lymphoblastic leukemia via suppressing proliferation and inducing cell cycle arrest with apoptosis

Chinese Medicine, 2022
Background Acute lymphoblastic leukemia is an aggressive neoplasm and seriously threatens human health. A14 is one kind of semisynthetic aurone that exhibits the capability to inhibit prostate cancer, but little is known about the role of A14 on T-cell ...
Meng Wang, Lisi Li, Tengyun Fan, Lixue Cao, Jiayi Zhang, Shuang Li, Chunming Liu, Xifu Liu   +7 more
doaj   +1 more source

Chemotactic Cues for NOTCH1-Dependent Leukemia [PDF]

, 2018
The NOTCH signaling pathway is a conserved signaling cascade that regulates many aspects of development and homeostasis in multiple organ systems.
Amadori, Alberto, Piovan, Erich, Tosello, Valeria, Zanovello, Paola   +3 more
core   +1 more source

Gene expression profiling identifies a subset of adult T-cell acute lymphoblastic leukemia with myeloid-like gene features and over-expression of miR-223

Haematologica, 2010
Background Until recently, few molecular aberrations were recognized in acute lymphoblastic leukemia of T-cell origin; novel lesions have recently been identified and a certain degree of overlap between acute myeloid leukemia and T-cell acute ...
Sabina Chiaretti, Monica Messina, Simona Tavolaro, Giuseppe Zardo, Loredana Elia, Antonella Vitale, Alessandro Fatica, Paolo Gorello, Alfonso Piciocchi, Gina Scappucci, Irene Bozzoni, Claudio Fozza, Anna Candoni, Anna Guarini, Robin Foà   +14 more
doaj   +1 more source

Machine learning strategies to predict late adverse effects in childhood acute lymphoblastic leukemia survivors [PDF]

arXiv, 2022
Acute lymphoblastic leukemia is the most frequent pediatric cancer. Approximately two third of survivors develop one or more health complications known as late adverse effects following their treatments. The existing measures offered to patients during their follow-up visits to the hospital are rather standardized for all childhood cancer survivors and
arxiv  

Uncovering low-dimensional, miR-based signatures of acute myeloid and lymphoblastic leukemias with a machine-learning-driven network approach [PDF]

Converg. Sci. Phys. Oncol. 1 (2015) 025002, 2014
Complex phenotypic differences among different acute leukemias cannot be fully captured by analyzing the expression levels of one single molecule, such as a miR, at a time, but requires systematic analysis of large sets of miRs. While a popular approach for analysis of such datasets is principal component analysis (PCA), this method is not designed to ...
arxiv   +1 more source