Pediatric Acute Lymphoblastic Leukemia
AbstractThe outcome for children with acute lymphoblastic leukemia (ALL) has improved dramatically with current therapy resulting in an event free survival exceeding 75% for most patients. However significant challenges remain including developing better methods to predict which patients can be cured with less toxic treatment and which ones will ...
Elizabeth A. Raetz+8 more
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Marrow transplantation for patients with acute lymphoblastic leukemia in remission [PDF]
ED Thomas+9 more
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Highly multiplexed and quantitative cell-surface protein profiling using genetically barcoded antibodies. [PDF]
Human cells express thousands of different surface proteins that can be used for cell classification, or to distinguish healthy and disease conditions.
Adams, Jarrett J+12 more
core +1 more source
HI A ASSOCIATION WITH CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA
Summary: OBJECTIVE Many associations have been found between specific HLA antigens and increased susceptibility to various diseases . So we tried to associate class I and class II antigens with acute lymphoblastic leukemia .
BATOOL M. MAHDI, salalwa M. Shareef
doaj +1 more source
GRFS and CRFS in alternative donor hematopoietic cell transplantation for pediatric patients with acute leukemia. [PDF]
We report graft-versus-host disease (GVHD)-free relapse-free survival (GRFS) (a composite end point of survival without grade III-IV acute GVHD [aGVHD], systemic therapy-requiring chronic GVHD [cGVHD], or relapse) and cGVHD-free relapse-free survival ...
Abdel-Azim, Hisham+53 more
core +2 more sources
Background: T-cell acute lymphoblastic leukemia is a hematologic malignancy characterized by T-cell proliferation, and in many cases, the ectopic expression of the oncogenic transcription factor T-cell acute lymphocytic leukemia protein 1 (TAL1 ...
Hongbo Sun MD+5 more
doaj +1 more source
Treatment of acute lymphoblastic leukemia in adolescents and a-dults: A retrospective study of 41 patients (1970-1973) [PDF]
Roel Willemze+3 more
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p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia [PDF]
Background: The t(9;22) translocation leads to the formation of the chimeric breakpoint cluster region/c-abl oncogene 1 (BCR/ABL) fusion gene on der22, the Philadelphia chromosome.
Mahajna, Jamal+5 more
core +2 more sources
The Notch driven long non-coding RNA repertoire in T-cell acute lymphoblastic leukemia
Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring ...
Kaat Durinck+17 more
doaj +1 more source
VH replacement in rearranged immunoglobulin genes [PDF]
Examples suggesting that all or part of the V<sub>H</sub> segment of a rearranged V<sub>H</sub>DJ<sub>H</sub> may be replaced by all or part of another V<sub>H</sub> have been appearing since the 1980s ...
Brokaw JL+21 more
core +2 more sources