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Giant mitochondria in acute lymphocytic leukemia
Experimental and Molecular Pathology, 1987Giant mitochondria were observed in 2 cases among 28 cases of ALL by electron microscopy. The cristae of the giant mitochondria in the leukemic cells were irregularly arranged, decreased in number, and formed concentric circles. Several morphological abnormalities were also observed in the normal mitochondria.
Hitoshi Sakakibara +6 more
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Angiogenesis in acute and chronic lymphocytic leukemia
Leukemia Research, 2004The bone marrow microenvironment plays a crucial role in leukemogenesis. Recent studies suggest that its vascularity changes significantly during this process and that angiogenic factors are of major importance in leukemia. This review summarizes the literature concerning the relationship between angiogenesis and the progression of acute and chronic ...
MOLICA S +4 more
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Acute lymphocytic leukemia cytochemistry and ultrastructure
Blut Zeitschrift für die Gesamte Blutforschung, 1974Cytochemical methods allow the distinction of a peculiar-PAS and β-glucuronidase positive-type of acute leukemia, which, according to previous authors, is termed acute lymphocytic leukemia (ALL). The cytochemical pattern suggests poor differentiation, which is confirmed by electron microscopic investigations.
Franz Schmalzl +7 more
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PATHOLOGIC DIAGNOSIS OF ACUTE LYMPHOCYTIC LEUKEMIA
Hematology/Oncology Clinics of North America, 2000With present knowledge, the optimal management of individual patients with acute leukemia requires that every case be studied by morphology, cytochemistry, cytogenetic, immunologic and molecular techniques. An algorithm for diagnostic evaluation and classification of ALL is provided in Fig. 11.
Carlos E. Bueso-Ramos +2 more
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Acute transformation of chronic lymphocytic leukemia
Medical and Pediatric Oncology, 1984AbstractA patient with chronic lymphocytic leukemia had typical cell morphology and a characteristic clinical course for 7 years. He then developed progressive disease with a rapidly rising WBC which proved resistant to chemotherapy. The cells resembled lymphoblasts.
Andrew D. Jacobs +2 more
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Emerging drugs for acute lymphocytic leukemia
Expert Opinion on Emerging Drugs, 2013Acute lymphoblastic leukemia (ALL) is typically treated with complex multi-agent chemotherapy regimens over a prolonged time period. Long-term outcomes depend on the age of the patient and the biological characteristics of the leukemic cells. While pediatric patients achieve cure more often than adults, therapy can continue to be improved for all ...
Michael S. Mathisen +2 more
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Cancer After Acute Lymphocytic Leukemia
Archives of Pediatrics & Adolescent Medicine, 1981Curing children of cancer is wonderful, but it is not without other risks, as we are beginning to learn. In 1964 only 2% of children with acute lymphocytic leukemia (ALL) survived five years. 1 Now, if treated with optimal therapy, 50% of these children survive five years or longer.
Robert W. Miller, Priscilla Ann Gilman
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Acute and Chronic Lymphocytic Leukemia
1984Acute lymphoblastic leukemia (ALL) in adults is a relatively rare disease, comprising approximately 20% of the acute leukemias in patients above 15 years of age.16 ALL is more common in children, comprising nearly 90% of the acute leukemias in patients under age 15 (Table 4–1).
Anne Moore +2 more
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Infectious Mononucleosis in Acute Lymphocytic Leukemia
JAMA: The Journal of the American Medical Association, 1965An 18-year-old high-school student was found to have lymphoblastic leukemia at the age of 16 years. Remission was obtained with weekly doses of 2 mg/sq m of body surface of vincristine sulfate and daily doses of 40 mg/ sq m of prednisone. Maintenance treatment with intramuscular administration of methotrexate, 30 mg/sq m twice weekly, was initiated ...
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Tisagenlecleucel-T for the treatment of acute lymphocytic leukemia
Expert Opinion on Biological Therapy, 2018Cellular immunotherapy with autologous or allogeneic T cells, genetically engineered to express chimeric antigen receptors (CARs) or T-cell receptors, in order to redirect their cytotoxic specificity toward malignant cells, is emerging as a promising new treatment modality.
Xavier Thomas, Etienne Paubelle
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