Results 81 to 90 of about 18,983 (198)

Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases

Advanced Science, Volume 13, Issue 14, 9 March 2026.
This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo, Lanjie Lei, Ying Jin, Lan Su, Shumao Cui, Liyun Shi   +5 more
wiley   +1 more source

The Partial Duplication of the 5′ Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid Leukemia

Case Reports in Pediatrics, 2017
The duplication of 5′ segment of KMT2A is a rare molecular event in childhood leukemia, and the influence on prognosis is unknown. Here, we report on a boy who developed acute monocytic leukemia.
Hiroko Fukushima, Toru Nanmoku, Sho Hosaka, Yuni Yamaki, Nobutaka Kiyokawa, Takashi Fukushima, Ryo Sumazaki   +6 more
doaj   +1 more source

Rare Case of Refractory Hypokalemia in a Patient with Acute Monocytic Leukemia. [PDF]

Am J Case Rep, 2023
Naseer M, Kania B, Ghrewati M, Mahmoud A, Faheem B, Singhal M.   +5 more
europepmc   +1 more source

Prolonged Release of IL‐10 From Enzyme‐Mediated Poly‐l‐(Tyrosine‐co‐Phenylalanine) Nanocrystals Enhances Stability and Modulates Inflammatory Responses

Biopolymers, Volume 117, Issue 2, March 2026.
Schematic representation of enzyme‐mediated peptide nanocrystal formation and IL‐10 encapsulation, providing stabilized and sustained cytokine delivery that modulates macrophage phenotype and reduces inflammatory responses. ABSTRACT Protease‐catalyzed synthesis of a peptide composed of l‐tyrosine and l‐phenylalanine (2.2:1 M ratio) was achieved in a ...
Fátima Landa‐Tencle, Carmen G. Hernández‐Valencia, Fernando Guzmán‐Lagunes, Carmina Montiel, Yoan Cuellar‐Entenza, Carlos Guerrero‐Sánchez, Steffi Stumpf, Stephanie Hoeppener, Ulrich S. Schubert, Yessica Zamudio‐Cuevas, Roberto Sánchez‐Sánchez, Miquel Gimeno   +11 more
wiley   +1 more source

Mendelian randomization analysis identifies HLA‐A and AP2M1 as genetic biomarkers linked to immune–endocytic crosstalk in intervertebral disc degeneration

Journal of Cell Communication and Signaling, Volume 20, Issue 1, March 2026.
HLA‐A and AP2M1 are identified as key endocytosis‐related biomarkers that modulate immune–endocytic crosstalk via mTOR signaling to regulate cell survival, immune infiltration, and the progression of intervertebral disc degeneration. Abstract Intervertebral disc degeneration (IVDD) is a major contributor to chronic spinal disorders, yet the role of ...
Yukui Tian, Xue Bai, Nianrong Han, Cheng Wang, Junchang Liu   +4 more
wiley   +1 more source

A Link Between Allergy and Hematological Malignancies? Focus on Possible Mechanisms and the Potential Role of Biological Therapies

Clinical and Translational Allergy, Volume 16, Issue 3, March 2026.
ABSTRACT Immune dysregulation has been widely recognized in the international literature as an underlying condition for hematological malignancies and allergic disorders. This commonality has led researchers to study the potential association, positive or negative, between blood cancers and allergy, but the results remain unclear.
Stefania Isola, Luca Gammeri, Federica Nuccio, Alessandro Allegra, Giorgio Walter Canonica, Sebastiano Gangemi   +5 more
wiley   +1 more source

Multiorgan Failure in Hemophagocytic Lymphohistiocytosis Secondary to Acute Monocytic Leukemia and Myocarditis in a Pediatric Patient. [PDF]

Cureus, 2023
Everett S, Dalo AM, Alejo AL, Ptasinski J.   +3 more
europepmc   +1 more source

Drug Delivery Systems for Resiquimod to Control Myeloid‐Derived Suppressor Cells in Cancer Immunotherapy

WIREs Nanomedicine and Nanobiotechnology, Volume 18, Issue 2, March/April 2026.
Myeloid‐derived suppressor cells (MDSCs) are key contributors to cancer immunotherapy failure and major targets in new therapeutic strategies. We highlight therapeutic approaches to counteract their immunosuppressive functions and discuss recent efforts to optimize drug delivery for controlling MDSCs, focusing on resiquimod as a representative drug ...
Yanying He, Yoon Yeo
wiley   +1 more source

Identification of the MYST3-CREBBP fusion gene in infants with acute myeloid leukemia and hemophagocytosis

Revista Brasileira de Hematologia e Hemoterapia
Background: Acute myeloid leukemia presenting the MYST3-CREBBP fusion gene is a rare subgroup associated with hemophagocytosis in early infancy and monocytic differentiation.
Francianne Gomes Andrade, Elda Pereira Noronha, Rosania Maria Baseggio, Teresa Cristina Cardoso Fonseca, Bruno Marcelo Rocha Freire, Isis M. Quezado Magalhaes, Ilana R. Zalcberg, Maria S. Pombo-de-Oliveira   +7 more
doaj   +1 more source

Post-cardiac Arrest Leukocytosis Mimicking Acute Monocytic Leukemia. [PDF]

Cureus, 2022
Kahlon N, Doddi S, Abuhelwa Z, Stanoszek L, Hamouda D.   +4 more
europepmc   +1 more source