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Immunotherapy of Acute Myeloid Leukemia
Current Pharmaceutical Biotechnology, 2001Most patients with acute myeloid leukemia (AML) respond initially to combination chemotherapy but later relapse. These patients often die from progressive disease or toxicities of further chemotherapy. At relapse, the patients' blasts are usually resistant to the drugs to which the patient has been exposed and frequently to other cytotoxic agents as ...
Arthur E. Frankel +3 more
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Transplantation in Acute Myeloid Leukemia
Hematology/Oncology Clinics of North America, 2014Acute myeloid leukemia (AML) is associated with poor outcome mainly because of relapse. The best antileukemic treatment is allogeneic stem cell transplantation. However, the associated significant nonrelapse mortality limits both the application and outcome of the procedure.
Tsila Zuckerman +2 more
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Acute myeloid leukemia in adults
Current Treatment Options in Oncology, 2000The treatment outcome for most adults with acute myeloid leukemia (AML) remains unacceptable. Additional agents or substitution of high-dose cytarabine for conventional-dose cytarabine during induction does not improve the remission rate or overall survival. There is substantial toxicity with high-dose cytarabine during induction.
Larry D. Cripe, Stuart Hinton
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Pharmacogenomics in Acute Myeloid Leukemia [PDF]
Pharmacogenomics, 2009 Acute myeloid leukemia (AML) in adults is a heterogeneous malignant pathology with a globally unfavorable prognosis. The classification of AML allows identification of subgroups with favorable prognosis. However, besides these specific subgroups, most patients will have an intermediate or unfavorable prognosis often resulting in induction failure ...
Christophe Roumier, Meyling Cheok
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Pediatric acute myeloid leukemia
Expert Review of Anticancer Therapy, 2012Pediatric acute myeloid leukemia (AML) is currently associated with survival rates as high as 70%. However, many events still occur, side effects are significant, and late effects occur and can even be life-threatening. Thus, the treatment of pediatric AML still needs further improvement.
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Immunotherapy for acute myeloid leukemia [PDF]
Current Oncology Reports, 2005 Immunotherapeutic strategies have become part of standard cancer treatment. Chimeric and humanized antibodies have demonstrated activity against a variety of tumors. Although the humanized anti-CD33 antibody HuM195 has only modest activity against overt acute myeloid leukemia (AML), it can eliminate minimal residual disease in acute promyelocytic ...
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Tipifarnib in acute myeloid leukemia
Drugs of Today, 2007Treatment of older patients with acute myeloid leukemia (AML) represents a significant challenge. There is little evidence that outcomes are improving for patients subjected to conventional intensive treatment. In addition, there is a large population of patients who are not considered fit for a more intensive treatment approach, and treatment options ...
Alan Kenneth Burnett, Jonathan Kell
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Decitabine in Acute Myeloid Leukemia
Seminars in Hematology, 2005Standard induction chemotherapy, depending on patient tolerability, is at present the treatment of choice in patients with acute myeloid leukaemia (AML) under the age of 75 years. Since AML is a disease primarily of the elderly, a large proportion of patients do not receive this therapy; therefore, novel treatment modalities are warranted. In addition,
Lübbert, Michael, Minden, Mark
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2007
The acute myeloid leukemias (AML) are a heterogeneous group of malignant diseases of hematopoietic progenitor cells with a spectrum of molecular genetic abnormalities, clinical characteristics, and variable outcomes with available treatments. A virtual explosion has been seen in the identification and characterization of disease alleles in AML in cell ...
Iris T. Chan, D. Gary Gilliland
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The acute myeloid leukemias (AML) are a heterogeneous group of malignant diseases of hematopoietic progenitor cells with a spectrum of molecular genetic abnormalities, clinical characteristics, and variable outcomes with available treatments. A virtual explosion has been seen in the identification and characterization of disease alleles in AML in cell ...
Iris T. Chan, D. Gary Gilliland
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New England Journal of Medicine, 1999
Löwenberg, Bob, Downing, JR, Burnett, A
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Löwenberg, Bob, Downing, JR, Burnett, A
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