Results 131 to 140 of about 360,402 (292)

Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics

open access: yesAdvanced Science, EarlyView.
Muralidharan and colleagues develop cell‐type‐specific transcriptomic aging clocks using single‐nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict age and identify distinct aging trajectories in specific brain cell types.
Chandramouli Muralidharan   +12 more
wiley   +1 more source

Implications of a new clinical classification of acute myocardial infarction. [PDF]

open access: yesEur Heart J Acute Cardiovasc Care
Thurston AJF   +4 more
europepmc   +2 more sources

Mitochondrial Transplantation Augments the Reparative Capacity of Macrophages Following Myocardial Injury

open access: yesAdvanced Science, EarlyView.
Mitochondrial transplantation induces macrophage polarization toward an anti‐inflammatory M2 phenotype, enhances their reparative capacities, and facilitates mitochondrial transfer to cardiomyocytes, collectively promoting tissue repair and functional recovery post‐myocardial infarction.
Yuning Zhang   +10 more
wiley   +1 more source

Comparing the diagnostic values of circulating microRNAs and cardiac troponin T in patients with acute myocardial infarction

open access: yesClinics, 2013
OBJECTIVE: Recent studies have shown that circulating microRNAs might be useful, novel biomarkers for the diagnosis of acute myocardial infarction. The aims of this study were to evaluate the expression of cardiac-specific miRNAs (miR-1, -133a, -208b ...
Ying-Qing Li   +9 more
doaj  

Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre‐mRNA

open access: yesAdvanced Science, EarlyView.
This work defines the context‐dependent function of Zc3h12c in macrophages using the Tnfrsf11a‐Cre system. It reveals Zc3h12c's dual mechanism—regulating RNA degradation and alternative splicing—with STAT1 as a key target. The findings elucidate a novel post‐transcriptional pathway and identify STAT1 isoforms as potential therapeutic targets for kidney
Chenyu Li   +14 more
wiley   +1 more source

Successful External Electrical Defibrillation in Acute Myocardial Infarction [PDF]

open access: bronze, 1960
Philip R. Nast   +2 more
openalex   +1 more source

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

open access: yesAdvanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li   +5 more
wiley   +1 more source

Survival after left ventricular free wall rupture due to acute myocardial infarction

open access: yesARYA Atherosclerosis, 2015
BACKGROUND: Left ventricular free wall rupture is a frequent catastrophic complication of acute myocardial infarction (AMI) and occurs in 1-3% of patients with acute myocardial infarction; it is the third most common cause of death caused by acute ...
Mahmood Hosseinzadeh-Maleki   +3 more
doaj  

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