Results 181 to 190 of about 651,453 (295)

Linezolid prevents fibroblast activation and ameliorates tissue fibrosis by inhibition of mitochondrial translation

open access: yesArthritis &Rheumatology, Accepted Article.
Background Beyond its role as a ribosome‐targeting antibiotic, linezolid was recently shown to modulate immune responses by inhibiting mitochondrial translation. Since mitochondrial dysfunction is implicated in various fibrotic diseases, including systemic sclerosis (SSc), this study aimed to evaluate the antifibrotic potential of linezolid and ...
Xuezhi Hong   +13 more
wiley   +1 more source

Effectiveness and safety of combining thiazides with loop diuretics vs. loop diuretics monotherapy in patients with acute decompensated heart failure: A retrospective cohort study

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims This study investigated factors associated with and outcomes of combined loop diuretics with hydrochlorothiazide (HCTZ) for acute decompensated heart failure (ADHF). Methods In this retrospective study, adults hospitalized for ADHF and who received intravenous loop diuretics between January 2016 and March 2023 were enrolled.
Chia‐Chen Hsu   +6 more
wiley   +1 more source

Sex differences in acute myocardial infarction: protocol for an umbrella review. [PDF]

open access: yesBMJ Open
Tørris C   +5 more
europepmc   +1 more source

Age‐related differences in hydroxychloroquine‐associated adverse events: A pharmacovigilance study based on the FDA Adverse Event Reporting System

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims This real‐world pharmacovigilance study utilizes FDA Adverse Event Reporting System (FAERS) data (2004–2024) to characterize age‐related disparities in hydroxychloroquine (HCQ)‐associated adverse events (AEs), addressing gaps in age‐stratified risk assessment. Methods Disproportionality analysis (reporting odds ratios, RORs) and parametric Weibull
Guanghan Sun   +4 more
wiley   +1 more source

Biomaterial design strategies for enhancing mitochondrial transplantation therapy

open access: yesBMEMat, EarlyView.
Biomaterials to facilitate mitochondrial transplantation therapy: biomaterials as barriers to protect mitochondria from pathophysiological microenvironments, like osmotic stress caused by the excessive concentration of calcium ion, reactive oxygen species, and advanced glycation end products; biomaterials integrating with biochemical cues to improve ...
Shaoyang Kang   +12 more
wiley   +1 more source

Coronary Artery Fistulous Perforation Effectively Managed During Chronic Total Occlusion Recanalization: A Case Report

open access: yesCatheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Coronary perforation is a feared complication of chronic total occlusion‐percutaneous coronary intervention (CTO‐PCI), especially in large vessel perforations, which often require implantation of covered stents (CS). However, the deployment of multiple CSs may not always be effective.
Gao Haokao   +3 more
wiley   +1 more source

Immunohistochemical Assessment of Acute Myocardial Infarction: A Systematic Review. [PDF]

open access: yesInt J Mol Sci
D'Antonio G   +8 more
europepmc   +1 more source

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