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Pediatric Acute-on-Chronic Liver Failure
Indian Journal of Pediatrics, 2023Acute-on-chronic liver failure (ACLF) is characterized by an acute hepatic insult happening in a patient with underlying cirrhosis with compromised hepatic reserve leading to development of systemic inflammation, sepsis, and organ failure resulting in poor outcome in majority.
Seema Alam, Bikrant Bihari Lal
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Acute-on-chronic Liver Failure
Current Gastroenterology Reports, 2016Acute-on-chronic liver failure (ACLF) is a distinct entity that differs from acute liver failure and decompensated cirrhosis in timing, presence of treatable acute precipitant, and course of disease, with a potential for self-recovery. The core concept is acute deterioration of existing liver function in a patient of chronic liver disease with or ...
Shiv Kumar, Sarin, Ashok, Choudhury
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Liver Transplantation in Acute-on-Chronic Liver Failure
Clinics in Liver Disease, 2023In recent years there has been a significant increase in the incidence of acute-on-chronic liver failure (ACLF). This syndrome is characterized by infections, organ failures, and high short-term mortality. Although progress in the management of these sick patients has been evident, liver transplantation (LT) remains the best treatment modality to date.
Anand V, Kulkarni, K Rajender, Reddy
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Liver Regeneration in Acute on Chronic Liver Failure
Clinics in Liver Disease, 2023Liver regeneration is a multifaceted process by which the organ regains its original size and histologic organization. In recent decades, substantial advances have been made in our understanding of the mechanisms underlying regeneration following loss of hepatic mass.
Madelyn J, Blake, Clifford J, Steer
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Acute on chronic liver failure
Gastroenterología y Hepatología, 2010Acute-on-Chronic Liver Failure (ACLF) is a recently introduced term defined as severe acute deterioration of an established liver disease. This entity usually develops after an acute insult. The main clinical manifestations are hepatorenal syndrome, hepatic encephalopathy and organ failure, with a high risk of death in the short term.
Angels, Escorsell Mañosa +1 more
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Liver Transplantation in Acute-on-chronic Liver Failure
Transplantation, 2020Liver transplantation (LT) has revolutionized outcomes for cirrhotic patients. Current liver allocation policies dictate patients with highest short-term mortality receive the highest priority, thus, several patients become increasingly ill on the waitlist.
Constantine J, Karvellas +2 more
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Pro: Acute‐on‐chronic liver failure
Liver Transplantation, 2017Liver Transplantation 23 1318–1324 2017 AASLD.
Solà, Elsa, Ginès, Pere
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Update on acute-on-chronic liver failure
Gastroenterología y Hepatología (English Edition), 2018Acute-on-chronic liver failure (ACLF) is a recently defined syndrome characterised by acute decompensation of chronic liver disease, associated with organ failures and high mortality. ACLF is a common condition and may affect up to 30% of patients admitted to hospital for cirrhosis complications.
Cristina, Solé, Elsa, Solà
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Overview on acute-on-chronic liver failure
Frontiers of Medicine, 2016Liver failure (LF) is defined as severe dysfunction in hepatic synthesis, detoxification, and metabolism induced by various etiologies. Clinical presentation of LF typically includes severe jaundice, coagulation disorder, hepatic encephalopathy, and ascites. LF can be classified into acute LF, acute-on-chronic LF (ACLF), and chronic LF.
Jing, Zhang +3 more
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