Results 211 to 220 of about 1,452,841 (291)

SLC2A3‐Mediated Lactate Metabolism Promotes Lung Cancer Bone Metastasis by Modulating P53 Lactylation and Immune Evasion

Advanced Science, EarlyView.
SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding, Yuying Tian, Wenjie Ren, Xianglin Hu, Mengjuan Li, Bei Liu, Chen chen, Yunhan Lu, Lei Li, Wangjun Yan, Kun Li   +10 more
wiley   +1 more source

Morphine Plus Placebo vs Morphine Plus Acetaminophen for Acute Pain in the Emergency Department: A Randomized Clinical Trial.

JAMA Netw Open
Cattin G, Viglino D, Segard J, Volteau C, Chauvin A, Galinski M, Maigre O, Delamare-Fauvel A, Le Pottier M, Debierre V, Chouihed T, Longo C, Jenvrin J, Freund Y, Montassier E.   +14 more
europepmc   +1 more source

Perceiving pain alters body perception: the effects of acute pain on body image and sensory testing. [PDF]

Pain
Budzisz A, Adamczyk WM, Luedtke K.
europepmc   +1 more source

Mechanical Overloading‐Induced Nanomineral Crystal Perturbation from the Osteochondral Interface: A Potential Initiator of Osteoarthritis

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Nan Jiang, Rong Ren, Zhan Su, Jiahao Zhou, Pinyin Cao, Sicheng Zhang, Zhen Li, Chao Li, Songsong Zhu   +8 more
wiley   +1 more source

Erector spinae plane block for acute pain management of pancreatic cancer at the emergency department. [PDF]

Ultrasound J
Adi O, Fong CP, Ahmad AH, Ghani MRA, Fathil S.   +4 more
europepmc   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Commentary on "Acute pain service for postoperative pain in adults: a network meta-analysis". [PDF]

Int J Surg
Zhang C, Xu R, Wen J.
europepmc   +1 more source

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

Opioid-free anesthesia: comparable analgesia with potential superiority in safety and quality of recovery

Journal of Anesthesia, Analgesia and Critical Care
Jan P. Mulier, Patrice Forget, Patricia Lavand’homme, Luc De Baerdemaeker, Hans D. de Boer   +4 more
doaj   +1 more source

Suzetrigine: A Novel Non-Opioid Analgesic for Acute Pain Management-A Review. [PDF]

Drugs Drug Candidates
Jones M, Demery A, Al-Horani RA.
europepmc   +1 more source