pMM‐PCL, made up of pretreated macrophage menbrane and polycaprolactone, boasts the adsorption of harmful myelin debris in the microenvironment of spinal cord injury. Abstract After spinal cord injury (SCI), a mass of myelin debris derived from injured myelin sheath will be consistently generated and induce macrophages to be foam cells.
Yuchen Zhou+7 more
wiley +1 more source
Impact of equine interactions on human acute pain perception: Two cross sectional studies. [PDF]
Doherty-Sneddon G+3 more
europepmc +1 more source
Electrochemical‐Genetic Programming of Protein‐Based Magnetic Soft Robots for Active Drug Delivery
This manuscript presents a protein‐based soft robot for active drug delivery. Stimuli‐responsive protein is rationally designed and processed into the substrate of robots. Superparamagnetic Fe3O4 nanoparticles are patterned on the substrate using an electrochemical method, enabling the robot to respond to external physical fields.
Hang Zhao+12 more
wiley +1 more source
Acute Pain Management in Peripheral Artery Disease: A Holistic, Beyond-Opioids, Individualized Multimodal Approach. [PDF]
Ntalouka MP+6 more
europepmc +1 more source
The fast adaptive focus tracking robotic optical coherence tomography (FACT‐ROCT) offers real‐time, high‐resolution imaging of spinal cord tumors during surgery. By reducing motion artifacts with robotics and adaptive focal tracking, it accurately differentiates tumor grades using a novel attenuation coefficient marker and reveals critical ...
Bin He+16 more
wiley +1 more source
Exploring Perceived Barriers and Facilitators for Implementing Acute Pain Clinical Trials: A Mixed-Methods Analysis of Ketamine Infusions for Sickle Cell Pain. [PDF]
Kenney MO+5 more
europepmc +1 more source
This study introduces a novel transdermal delivery system of molecular hydrogen for postoperative pain relief and wound healing. This system utilizes sustained‐release photothermal microneedles to integrate hydrogen‐releasing nanoparticles and temperature‐responsive microspheres, achieving acid‐responsive hydrogen release and controlled drug release ...
Aining Zhang+8 more
wiley +1 more source
A clinical decision support tool for acute pain within an electronic health record to improve analgesic prescribing practice. [PDF]
O'Hagan M, Johnson D, Lobo DN, Levy N.
europepmc +1 more source
The Locus Coeruleus‐Periaqueductal Gray GABAergic Projection Regulates Comorbid Pain and Depression
LC‐GABA neurons exhibit elevated activity to noxious and aversive stimuli in chronic pain, and their activation alleviates pain‐ and depression‐like behaviors. While LC‐GABA neurons target LC‐NA neurons and GABA and Glu neurons in the vlPAG, they modulate the pain responses of LC‐NA neurons but regulate pain‐ and depression‐like behaviors through their
Yuan Gao+7 more
wiley +1 more source
A novel opioid/pramipexole combination treatment for the management of acute pain: a pilot study. [PDF]
Girardi C+5 more
europepmc +1 more source