Results 91 to 100 of about 333,750 (340)

Corneal Allograft Rejection: Immunopathogenesis to Therapeutics [PDF]

, 2014
Corneal transplantation is among the most successful solid organ transplants. However, despite low rejection rates of grafts in the ‘low-risk’ setting, rejection can be as high as 70% when grafted into ‘high-risk’ recipient beds. Under normal homeostatic
Hamrah, Pedram, Qazi, Yureeda
core   +1 more source

Anionic Citrate‐Based 3D‐Printed Scaffolds for Tunable and Sustained Orthobiologic Delivery to Enhance Tissue Regeneration

Advanced Functional Materials, EarlyView.
A potent anionic citric acid‐based 3D‐printed scaffold is developed for the sustained and controlled release of orthobiologics to enhance orthopedic therapeutic efficacy. Comprehensive in vivo studies demonstrated effective bone fusion and high safety at a low dose of BMP‐2 delivered by the system, establishing it as a promising platform for safe ...
Se‐Hwan Lee, Ruqiang Lu, Andrew House, Zizhao Li, Lindsey Hammond Burton, Katie Josephine Sikes, Lynn Marie Pezzanite, Drew William Koch, Kevin Michael Labus, Ben Gadomski, Jeremiah Easley, Richard Tuan Tran, Su Chin Heo   +12 more
wiley   +1 more source

B-Cell Activating Factor Predicts Acute Rejection Risk in Kidney Transplant Recipients: A 6-Month Follow-Up Study

Frontiers in Immunology, 2019
B cell activating factor (BAFF) belonging to TNF family is a cytokine that enhances B-cell proliferation and differentiation. Recently, It has been suggested that BAFF might be a potential therapeutic target for treating autoimmune disease.
Xu-Zhen Wang, Zhen Wan, Wu-Jun Xue, Jin Zheng, Yang Li, Chen Guang Ding   +5 more
doaj   +1 more source

Simultaneous administration of adjuvant donor bone marrow in pancreas transplant recipients [PDF]

, 1999
Objective: The effect of donor bone marrow was evaluated for its potentially favorable effect in the authors' simultaneous pancreas/kidney transplant program.
Abdul S. Rao, Carlos A. Vivas, Corry, Corry, Corry, Corry, Corry, Egidi, Fioretto, Fontes, Greussner, Gruessner, Igor Dvorchik, John J. Fung, Jordan, Kapur, Mark L. Jordan, Nghiem, Pinna, Pradip K. Chakrabarti, Rao, Robert J. Corry, Ron Shapiro, Scantlebury, Shapiro, Sollinger, Starzl, Starzl, Starzl, Sugitani, Thomas E. Starzl, Tyden, Tyden, Velma P. Scantlebury, Wakely, Zehr   +35 more
core   +2 more sources

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Fk506 “rescue” for resistant rejection of renal allografts under primary cyclosporine immunosuppression [PDF]

, 1994
Seventy-seven patients with ongoing acute rejection on initial CsA therapy were converted to FK506 to attempt graft salvage. Fifty-nine patients had undergone primary transplantation and 18 had been retransplanted; there were 52 cadaveric and 25 living ...
Carrieri, G, Demetris, AJ, Fung, JJ, Hakala, TR, Jordan, ML, Mc Cauley, J, Rhandhawa, P, Scantlebury, VP, Shapiro, R, Simmons, RL, Starzl, TE, Tzakis, A, Vivas, CA   +12 more
core   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

A risk assessment model of acute liver allograft rejection by genetic polymorphism of CD276

Molecular Genetics & Genomic Medicine, 2019
Background Liver transplantation is an effective therapy for end‐stage liver diseases and acute liver failure. After the operation, however, recipients may suffer grafts loss induced by alloimmune reaction, which is termed as acute allograft rejection ...
Xiaobo Yu, Bajin Wei, Rong Su, Jia Yao, Xiaowen Feng, Guoping Jiang, Haiyang Xie, Jian Wu, Xiao Xu, Min Zhang, Shusen Zheng, Lin Zhou   +11 more
doaj   +1 more source

Increased numbers of circulating CD8 effector memory T cells before transplantation enhance the risk of acute rejection in lung transplant recipients.

PLoS ONE, 2013
The effector and regulatory T cell subpopulations involved in the development of acute rejection episodes in lung transplantation remain to be elucidated.
David San Segundo, María Ángeles Ballesteros, Sara Naranjo, Felipe Zurbano, Eduardo Miñambres, Marcos López-Hoyos   +5 more
doaj   +1 more source

A prospective randomized trial of fk506 versus cyclosporine after human pulmonary transplantation [PDF]

, 1994
We have conducted a unique prospective randomized study to compare the effect of PK506 and cyclosporine (CsA) as the principal immunosuppressive agents after pulmonary transplantation.
Armitage, JM, Bando, KO, Fung, JJ, Griffith, BP, Hardesty, RL, Keenan, RJ, Komatsu, K, Konishi, H, Paradis, IL, Pham, SM, Starzl, TE, Yousem, SA   +11 more
core   +1 more source